Trilaciclib Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 8, 2024.

Applies to trilaciclib: intravenous powder for solution.

Precautions

It is very important that your doctor check your progress closely and at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Receiving this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Use an effective form of birth control to keep from getting pregnant during treatment and for at least 3 weeks after the last dose. If you think you have become pregnant while receiving the medicine, tell your doctor right away.

This medicine may cause serious injection-site reactions (eg, phlebitis, thrombophlebitis). Check with your doctor right away if you have bluish color, changes in skin color, or pain, tenderness, or swelling at the injection site.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Check with your doctor right away if you have a rash, itching, hives or welts, redness of the skin, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or tongue while you are using this medicine.

This medicine may cause lung or breathing problems (eg, interstitial lung disease, pneumonitis), which can be life-threatening. Check with your doctor right away if you have chest pain, chills, cough, fever, general feeling of discomfort or illness, thickening of bronchial secretions, or trouble breathing.

Talk with your doctor before using this medicine if you plan to have children. Some women who use this medicine have become infertile (unable to have children).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of trilaciclib

Along with its needed effects, trilaciclib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking trilaciclib:

For healthcare professionals

Applies to trilaciclib: intravenous powder for injection.

General adverse events

The most common adverse reactions were fatigue, hypocalcemia, hypokalemia, hypophosphatemia, aspartate aminotransferase increased, headache, and pneumonia^[Ref]

Hypersensitivity

• Common (1% to 10%): Infusion related reaction, anaphylaxis^[Ref]

Local

• Common (1% to 10%): Infusion-related reaction, asthenia^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Myositis^[Ref]

Hepatic

• Very common (10% or more): Increased aspartate aminotransferase (17%)^[Ref]

Respiratory

• Common (1% to 10%): Pneumonia (10%)
• Uncommon (0.1% to 1%): Respiratory failure^[Ref]

Other

Fatal adverse reactions included pneumonia, respiratory failure, acute respiratory failure, hemoptysis, and cerebrovascular accident^[Ref]

Hematologic

• Very common (10% or more): Neutropenia (32%), anemia (16%), thrombocytopenia (18%)
• Common (1% to 10%): Thrombosis, febrile neutropenia, leukopenia
• Uncommon (0.1% to 1%): Hemoptysis, lymphopenia^[Ref]

Nervous system

• Very common (10% or more): Fatigue (34%), headache (13%)^[Ref]

Cardiovascular

• Common (1% to 10%): Peripheral edema, thrombosis
• Uncommon (0.1% to 1%): Cerebrovascular accident, ischemic stroke^[Ref]

Dermatologic

• Common (1% to 10%): Skin rash, urticaria^[Ref]

Endocrine

• Very common (10% or more): Hypocalcemia (24%), hypokalemia (22%), hypophosphatemia (21%)
• Common (1% to 10%): Hyperglycemia^[Ref]

Gastrointestinal

• Common (1% to 10%): Upper abdominal pain^[Ref]

See also:

Further information

Trilaciclib side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer