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Trilaciclib Side Effects

Medically reviewed by Last updated on Jun 20, 2023.

Applies to trilaciclib: intravenous powder for solution.

Serious side effects of Trilaciclib

Along with its needed effects, trilaciclib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking trilaciclib:

More common

For Healthcare Professionals

Applies to trilaciclib: intravenous powder for injection.


Very common (10% or more): Neutropenia (32%), anemia (16%), thrombocytopenia (18%)

Common (1% to 10%): Thrombosis, febrile neutropenia, leukopenia

Uncommon (0.1% to 1%): Hemoptysis, lymphopenia[Ref]


Common (1% to 10%): Infusion related reaction, anaphylaxis[Ref]


Common (1% to 10%): Infusion-related reaction, asthenia[Ref]


Uncommon (0.1% to 1%): Myositis[Ref]


Very common (10% or more): Increased aspartate aminotransferase (17%)[Ref]


Common (1% to 10%): Pneumonia (10%)

Uncommon (0.1% to 1%): Respiratory failure[Ref]


Fatal adverse reactions included pneumonia, respiratory failure, acute respiratory failure, hemoptysis, and cerebrovascular accident[Ref]


The most common adverse reactions were fatigue, hypocalcemia, hypokalemia, hypophosphatemia, aspartate aminotransferase increased, headache, and pneumonia[Ref]

Nervous system

Very common (10% or more): Fatigue (34%), headache (13%)[Ref]


Common (1% to 10%): Peripheral edema, thrombosis

Uncommon (0.1% to 1%): Cerebrovascular accident, ischemic stroke[Ref]


Common (1% to 10%): Skin rash, urticaria[Ref]


Very common (10% or more): Hypocalcemia (24%), hypokalemia (22%), hypophosphatemia (21%)

Common (1% to 10%): Hyperglycemia[Ref]


Common (1% to 10%): Upper abdominal pain[Ref]


1. (2021) "Product Information. Cosela (trilaciclib)." G1 Therapeutics, Inc.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.