Razadyne ER Side Effects

Generic name: galantamine

Medically reviewed by Drugs.com. Last updated on Oct 25, 2024.

Note: This document provides detailed information about Razadyne ER Side Effects associated with galantamine. Some dosage forms listed on this page may not apply specifically to the brand name Razadyne ER.

Applies to galantamine: oral capsule extended release, oral solution, oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to check for unwanted effects.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine.

Galantamine may cause stomach or bowel problems. Check with your doctor right away if you have nausea, vomiting, diarrhea, stomach pain, loss of appetite, or weight loss.

If you think you or someone else may have taken an overdose of galantamine (the active ingredient contained in Razadyne ER) get emergency help at once. Taking an overdose of galantamine may lead to convulsions (seizures) or shock. Some signs of shock are large pupils, irregular breathing, and fast weak pulse. Other signs of an overdose are severe nausea and vomiting, increasing muscle weakness, greatly increased sweating, and greatly increased watering of the mouth.

Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines, such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems.

Common side effects of Razadyne ER

Some side effects of galantamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Razadyne ER

Along with its needed effects, galantamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking galantamine:

Get emergency help immediately if any of the following symptoms of overdose occur while taking galantamine:

Symptoms of overdose

• confusion
• convulsions
• irregular, fast or slow, or shallow breathing
• muscle weakness
• pale or blue lips, fingernails, or skin
• severe nausea
• stomach cramps
• sweating
• tearing of the eyes
• twitches of the muscle visible under the skin
• vomiting

For healthcare professionals

Applies to galantamine: oral capsule extended release, oral solution, oral tablet.

General adverse events

The most common side effects associated with discontinuation were nausea, vomiting, decreased appetite, dizziness, diarrhea, headache, and decreased appetite.^[Ref]

Dermatologic

• Frequency not reported: Hyperhidrosis
• Postmarketing reports: Stevens-Johnson syndrome, Acute generalized exanthematous pustulosis, Erythema multiforme

Gastrointestinal

• Very common (10% or more): Nausea, vomiting
• Common (1% to 10%): Diarrhea, abdominal pain, upper abdominal pain, dyspepsia, stomach discomfort, abdominal discomfort
• Uncommon (0.1% to 1%): Retching
• Postmarketing reports: Upper and lower GI bleeding, stomach discomfort, and abdominal discomfort.^[Ref]

The median duration of nausea in clinical trials was 5 to 7 days. The most commonly occurring adverse reactions associated with discontinuation have include nausea (6.2%), vomiting (3.3%), decreased appetite (1.5%), and dizziness (1.3%).^[Ref]

Cardiovascular

• Common (1% to 10%): Syncope, bradycardia
• Frequency not reported: First degree atrioventricular (AV) block, palpitations, sinus bradycardia, supraventricular extrasystoles, flushing, hypotension
• Postmarketing reports: Complete AV block, hypertension^[Ref]

Two randomized, placebo controlled trials revealed increased deaths in galantamine-treated patients with mild cognitive impairment. A total of 13 deaths occurred among galantamine-treated patients (n=1026) and 1 patient on placebo (n=1022). The deaths were due to various causes; about half of the galantamine deaths appeared to result from various vascular causes (myocardial infarction, stroke, and sudden death).^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection, hematuria
• Frequency not reported: Increased libido^[Ref]

Hematologic

• Common (1% to 10%): Anemia^[Ref]

Hepatic

• Postmarketing reports: Hepatitis, increased hepatic enzymes

Hypersensitivity

• Postmarketing reports: Hypersensitivity

Metabolic

• Common (1% to 10%): Decreased appetite, decreased weight, anorexia
• Uncommon (0.1% to 1%): Dehydration

Musculoskeletal

• Common (1% to 10%): Muscle spasms
• Uncommon (0.1% to 1%): Muscular weakness

Nervous system

• Common (1% to 10%): Headache, dizziness, tremor, somnolence, lethargy
• Frequency not reported: Dysgeusia, hypersomnia, paresthesia
• Postmarketing reports: Seizures^[Ref]

Ocular

• Uncommon (0.1% to 1%): Blurred vision

Other

• Common (1% to 10%): Fatigue, asthenia, malaise
• Uncommon (0.1% to 1%): Fall
• Postmarketing reports: Tinnitus

Psychiatric

• Common (1% to 10%): Depression
• Frequency not reported: Apathy, paranoia (disagreeable or terrifying dreams), paranoid reaction, increased libido, delirium, suicidal ideation and suicide
• Postmarketing reports: Hallucination, visual hallucination, auditory hallucination^[Ref]

Respiratory

• Common (1% to 10%): Rhinitis^[Ref]

See also:

Frequently asked questions

• Is Razadyne (galantamine) used to treat Alzheimer’s?

Further information

Razadyne ER side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer