Medically reviewed on March 10, 2017.
Applies to the following strengths: 4 mg; 8 mg; 12 mg; 4 mg/mL; 16 mg; 24 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Alzheimer's Disease
Immediate release tablet and oral solution:
Initial dose: 4 mg orally twice a day, preferably with morning and evening meals.
Maintenance dose: After a minimum of four weeks of treatment, if the initial dosage is well tolerated, it should be increased to 8 mg twice a day. A further increase to 12 mg twice a day should be attempted only after a minimum of 4 weeks at the previous dosage.
Maximum dose: 16 to 24 mg/day
Extended release capsule:
Initial dose: 8 mg orally daily, preferably with the morning meal.
Maintenance dose: After a minimum of four weeks of treatment, if the initial dosage is well tolerated, it should be increased to 16 mg once a day. A further increase to 24 mg once a day should be attempted only after a minimum of 4 weeks at the previous dosage.
Maximum dose: 16 to 24 mg/day
-Dose increases should be based upon assessment of clinical benefit and tolerability of the previous dose.
-If therapy has been interrupted for more than 3 days, the patient should be restarted at the lowest dosage and the dosage escalated to the current dose.
-Abrupt withdrawal of galantamine was not associated with increased frequency of adverse events
-The beneficial effects of galantamine are lost when the drug is discontinued
Renal Dose Adjustments
Moderate renal impairment: The dose should generally not exceed 16 mg/day.
Severe renal impairment (CrCl less than 9 mL/min): The use of galantamine is not recommended.
Liver Dose Adjustments
Moderately Impaired Hepatic Function (Child-Pugh score of 7 to 9): The dose should generally not exceed 16 mg/day.
Severe Hepatic Impairment (Child-Pugh score of 10 to 15): The use of galantamine is not recommended.
Conversion from Razadyne Tablets or Oral Solution to Razadyne ER:
-Take the last dose of Razadyne tablets or oral solution in the evening and starting Razadyne ER once daily the next morning.
-Converting from Razadyne to Razadyne ER should occur at the same total daily dosage.
Consult WARNINGS section for dosing related precautions.
Data not available
-Adequate fluid intake should be ensured during treatment
-The instruction sheet for the correct procedure for administering galantamine oral solution should be followed.
Storage requirements: Do not freeze the oral solution
Reconstitution/preparation techniques: Refer to the manufacturer's product information for use of Razadyne Oral Solution
General: Patients treated with galantamine up to 24 mg/day using the recommended dosing schedule showed a dose-related increase in risk of syncope.
Patient advice: Most frequent side effects associated with galantamine can be minimized by following the recommended dosage and administration
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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