Applies to the following strength(s): 4 mg ; 8 mg ; 12 mg ; 4 mg/mL ; 16 mg ; 24 mg
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Alzheimer's Disease
Immediate release tablet and oral solution:
Initial dose: 4 mg orally twice a day, preferably with morning and evening meals.
Maintenance dose: After a minimum of four weeks of treatment, if the initial dosage is well tolerated, it should be increased to 8 mg twice a day. A further increase to 12 mg twice a day should be attempted only after a minimum of 4 weeks at the previous dosage.
Maximum dose: 16 to 24 mg/day
Extended release capsule:
Initial dose: 8 mg orally daily, preferably with the morning meal.
Maintenance dose: After a minimum of four weeks of treatment, if the initial dosage is well tolerated, it should be increased to 16 mg once a day. A further increase to 24 mg once a day should be attempted only after a minimum of 4 weeks at the previous dosage.
Maximum dose: 16 to 24 mg/day
-Dose increases should be based upon assessment of clinical benefit and tolerability of the previous dose.
-If therapy has been interrupted for more than 3 days, the patient should be restarted at the lowest dosage and the dosage escalated to the current dose.
-Abrupt withdrawal of galantamine was not associated with increased frequency of adverse events
-The beneficial effects of galantamine are lost when the drug is discontinued
Renal Dose Adjustments
Moderate renal impairment: The dose should generally not exceed 16 mg/day.
Severe renal impairment (CrCl less than 9 mL/min): The use of galantamine is not recommended.
Liver Dose Adjustments
Moderately Impaired Hepatic Function (Child-Pugh score of 7 to 9): The dose should generally not exceed 16 mg/day.
Severe Hepatic Impairment (Child-Pugh score of 10 to 15): The use of galantamine is not recommended.
Conversion from Razadyne Tablets or Oral Solution to Razadyne ER:
-Take the last dose of Razadyne tablets or oral solution in the evening and starting Razadyne ER once daily the next morning.
-Converting from Razadyne to Razadyne ER should occur at the same total daily dosage.
Consult WARNINGS section for dosing related precautions.
Data not available
-Adequate fluid intake should be ensured during treatment
-The instruction sheet for the correct procedure for administering galantamine oral solution should be followed.
Storage requirements: Do not freeze the oral solution
Reconstitution/preparation techniques: Refer to the manufacturer's product information for use of Razadyne Oral Solution
General: Patients treated with galantamine up to 24 mg/day using the recommended dosing schedule showed a dose-related increase in risk of syncope.
Patient advice: Most frequent side effects associated with galantamine can be minimized by following the recommended dosage and administration
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