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Pulmozyme Side Effects

Generic Name: dornase alfa

Note: This page contains side effects data for the generic drug dornase alfa. It is possible that some of the dosage forms included below may not apply to the brand name Pulmozyme.

In Summary

Common side effects of Pulmozyme include: transient skin rash and voice disorder. Other side effects include: laryngitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dornase alfa: inhalation solution

As well as its needed effects, dornase alfa (the active ingredient contained in Pulmozyme) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking dornase alfa, check with your doctor immediately:

More common:
  • Body aches or pain
  • chest pain
  • congestion
  • cough
  • dryness or soreness of the throat
  • fever
  • hoarseness
  • runny nose
  • tender, swollen glands in the neck
  • trouble breathing
  • trouble swallowing
  • voice changes

Minor Side Effects

Some dornase alfa side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Acid or sour stomach
  • belching
  • heartburn
  • indigestion
  • rash
  • sneezing
  • stomach discomfort, upset, or pain
  • stuffy nose
Less common:
  • Burning, dry, or itching eyes
  • discharge or excessive tearing
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

For Healthcare Professionals

Applies to dornase alfa: inhalation solution

Dermatologic

Very common (10% or more): Rash (up to 12%)
Rare (less than 0.1%): Urticaria[Ref]

Musculoskeletal

Very common (10% or more): Chest pain (up to 25%)[Ref]

Other

Very common (10% or more): Fever (up to 32%), voice alteration (up to 18%)[Ref]

Respiratory

Very common (10% or more): Pharyngitis (up to 40%), rhinitis (up to 30%), dyspnea (up to 17%)
Common (1% to 10%): Laryngitis, Force Vita Capacity (FVC) decreased of 10% of predicted
Rare (less than 0.1%): Chest pain (pleuritic/non-cardiac), dysphonia, pulmonary function tests decreased[Ref]

Gastrointestinal

Common (1% to 10%): Dyspepsia[Ref]

Immunologic

Common (1% to 10%): Development of serum antibodies (2% to 4%)[Ref]

Ocular

Common (1% to 10%): Conjunctivitis[Ref]

References

1. "Product Information. Pulmozyme (dornase alfa)." Genentech, South San Francisco, CA.

2. Bryson HM, Sorkin EM "Dornase alfa. A review of its pharmacological properties and therapeutic potential in cystic fibrosis." Drugs 48 (1994): 894-906

3. Cerner Multum, Inc. "Australian Product Information." O 0

4. Witt DM, Anderson L "Dornase alfa: a new option in the management of cystic fibrosis." Pharmacotherapy 16 (1996): 40-8

5. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of Pulmozyme may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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