Pulmozyme Side Effects
Generic name: dornase alfa
Medically reviewed by Drugs.com. Last updated on Sep 18, 2024.
Note: This document provides detailed information about Pulmozyme.
Applies to dornase alfa: inhalation solution Side Effects associated with dornase alfa. Some dosage forms listed on this page may not apply specifically to the brand name Pulmozyme.
Applies to dornase alfa: inhalation solution.
Precautions
It is very important that your doctor check the progress of you or your child at regular visits. This is to make sure that the medicine is working properly and to check for unwanted effects.
If your or your child's condition becomes worse while you are using this medicine, check with your doctor right away.
If any of your medicines do not seem to be working as well as usual, call your doctor right away. Do not change your doses or stop using your medicines without asking your doctor.
Serious side effects of Pulmozyme
Along with its needed effects, dornase alfa (the active ingredient contained in Pulmozyme) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking dornase alfa:
More common side effects
Other side effects of Pulmozyme
Some side effects of dornase alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- rash
- sneezing
- stuffy nose
Less common side effects
- acid or sour stomach
- belching
- burning, dry, or itching eyes
- discharge or excessive tearing
- heartburn
- indigestion
- redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
- stomach discomfort, upset, or pain
For healthcare professionals
Applies to dornase alfa: inhalation solution.
Dermatologic adverse events
Musculoskeletal
- Very common (10% or more): Chest pain (up to 25%)[Ref]
Other
- Very common (10% or more): Fever (up to 32%), voice alteration (up to 18%)[Ref]
Respiratory
- Very common (10% or more): Pharyngitis (up to 40%), rhinitis (up to 30%), dyspnea (up to 17%)
- Common (1% to 10%): Laryngitis, Force Vita Capacity (FVC) decreased of 10% of predicted
- Rare (less than 0.1%): Chest pain (pleuritic/non-cardiac), dysphonia, pulmonary function tests decreased[Ref]
Gastrointestinal
Immunologic
- Common (1% to 10%): Development of serum antibodies (2% to 4%)[Ref]
Ocular
- Common (1% to 10%): Conjunctivitis[Ref]
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References
1. Bryson HM, Sorkin EM (1994) "Dornase alfa. A review of its pharmacological properties and therapeutic potential in cystic fibrosis." Drugs, 48, p. 894-906
2. Witt DM, Anderson L (1996) "Dornase alfa: a new option in the management of cystic fibrosis." Pharmacotherapy, 16, p. 40-8
3. (2001) "Product Information. Pulmozyme (dornase alfa)." Genentech
4. Cerner Multum, Inc. "UK Summary of Product Characteristics."
5. Cerner Multum, Inc. "Australian Product Information."
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Further information
Pulmozyme side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.