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Ponesimod Side Effects

Medically reviewed by Last updated on Aug 13, 2023.

Applies to ponesimod: oral tablet.

Serious side effects of Ponesimod

Along with its needed effects, ponesimod may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ponesimod:

More common

Less common


Other side effects of Ponesimod

Some side effects of ponesimod may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to ponesimod: oral tablet.


-The most common adverse reactions occurring in more than 10% of patients taking this drug included upper respiratory infection (37%), increased hepatic transaminase (23%) and hypertension (up to 10%).[Ref]


Very common (10% or more): Hypertension (up to 10%)

Common (1% to 10%): Bradycardia[Ref]



Uncommon (0.1% to 1%): Basal cell carcinoma, melanoma

Frequency not reported: Squamous cell carcinoma


Common (1% to 10%): Dyspepsia, dry mouth


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Increased C-reactive protein, lymphopenia[Ref]


Very common (10% or more): Increased hepatic transaminase (23%, includes ALT, AST)[Ref]

Most patients with ALT increases of 3 times or greater than the upper limit of normal resolved on continued treatment with this drug within approximately 2-4 weeks.[Ref]


Common (1% to 10%): Hypercholesterolemia, hyperkalemia[Ref]


Common (1% to 10%): Pain in extremity, joint swelling, back pain, ligament sprain, arthralgia[Ref]

Nervous system

Common (1% to 10%): Dizziness, somnolence, migraine, seizures, hypoesthesia[Ref]


Common (1% to 10%): Macular edema[Ref]


Common (1% to 10%): Chest discomfort, fatigue, peripheral edema, pyrexia, vertigo, viral infection, herpes zoster[Ref]


Common (1% to 10%): Insomnia, depression, anxiety


Upper respiratory infections included: nasopharyngitis, upper respiratory tract infection, pharyngitis, respiratory tract infection, bronchitis, respiratory tract infection viral, viral upper respiratory tract infection, tracheitis, and laryngitis.[Ref]

Very common (10% or more): Upper respiratory infection (37%)

Common (1% to 10%): Cough, dyspnea, rhinitis, sinusitis

Frequency not reported: Pneumonia[Ref]


1. Product Information. Ponvory (ponesimod). Janssen Pharmaceuticals. 2021.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.