Podofilox topical Side Effects

For the Consumer

Applies to podofilox topical: topical gel/jelly, topical solution

Along with its needed effects, podofilox topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking podofilox topical:

• Bad odor (solution only)
• bleeding of treated skin
• blistering, crusting, or scabbing of treated skin
• bloody urine (solution only)
• burning feeling of treated skin
• dizziness (solution only)
• headache (gel only)
• itching of treated skin
• pain during sexual intercourse (solution only)
• pain of treated skin
• problems with foreskin of penis (solution only)
• redness or swelling of treated skin
• scarring of treated skin (solution only)
• skin ulcers of treated skin
• vomiting (solution only)

• Nausea
• vomiting
• diarrhea
• chills
• fever
• sore throat
• unusual bleeding or bruising
• oral ulcers

Some side effects of podofilox topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Dryness of treated skin
• peeling of treated skin
• soreness or tenderness of treated skin
• stinging or tingling of treated skin
• trouble in sleeping (solution only)

• Changes in color of treated skin (gel only)
• skin rash (gel only)

For Healthcare Professionals

Applies to podofilox topical: topical gel, topical solution

Gastrointestinal

Gastrointestinal side effects have included vomiting.^[Ref]

Local

Local side effects have included burning, pain, inflammation, erosion, itching, and bleeding. Reports of burning and pain were greater and more severe in women than in men. Tenderness, chafing, malodor, scarring, vesicle formation, crusting edema, dryness, peeling, and ulceration have also been reported.^[Ref]

Genitourinary

Genitourinary side effects have included pain with intercourse, foreskin irretraction, and hematuria.^[Ref]

Nervous system

Nervous system side effects have included headache, insomnia, and dizziness.^[Ref]

Some side effects of podofilox topical may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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