Podofilox Topical Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 12, 2025.

Applies to podofilox topical: topical gel/jelly, topical solution.

Precautions

Podofilox may not be able to prevent previously healed warts from reappearing or stop new warts from growing.

This medicine contains alcohol and therefore may be flammable. Do not use near heat, near open flame, or while smoking.

Serious side effects of podofilox topical

Along with its needed effects, podofilox topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking podofilox topical:

Symptoms of overdose

• Nausea
• vomiting
• diarrhea
• chills
• fever
• sore throat
• unusual bleeding or bruising
• oral ulcers

Other side effects of podofilox topical

Some side effects of podofilox topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

See also:

For healthcare professionals

Applies to podofilox topical: topical gel, topical solution.

Gastrointestinal adverse events

Gastrointestinal side effects have included vomiting.^[Ref]

Local

Local side effects have included burning, pain, inflammation, erosion, itching, and bleeding. Reports of burning and pain were greater and more severe in women than in men. Tenderness, chafing, malodor, scarring, vesicle formation, crusting edema, dryness, peeling, and ulceration have also been reported.^[Ref]

Genitourinary

Genitourinary side effects have included pain with intercourse, foreskin irretraction, and hematuria.^[Ref]

Nervous system

Nervous system side effects have included headache, insomnia, and dizziness.^[Ref]

Further information

Podofilox topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer