Podofilox topical Side Effects

For the Consumer

Applies to podofilox topical: topical gel/jelly, topical solution

As well as its needed effects, podofilox topical may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking podofilox topical, check with your doctor or nurse as soon as possible:

• Bad odor (solution only)
• bleeding of treated skin
• blistering, crusting, or scabbing of treated skin
• bloody urine (solution only)
• burning feeling of treated skin
• dizziness (solution only)
• headache (gel only)
• itching of treated skin
• pain during sexual intercourse (solution only)
• pain of treated skin
• problems with foreskin of penis (solution only)
• redness or swelling of treated skin
• scarring of treated skin (solution only)
• skin ulcers of treated skin
• vomiting (solution only)

• Nausea
• vomiting
• diarrhea
• chills
• fever
• sore throat
• unusual bleeding or bruising
• oral ulcers

Minor Side Effects

Some podofilox topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

• Dryness of treated skin
• peeling of treated skin
• soreness or tenderness of treated skin
• stinging or tingling of treated skin
• trouble in sleeping (solution only)

• Changes in color of treated skin (gel only)
• skin rash (gel only)

For Healthcare Professionals

Applies to podofilox topical: topical gel, topical solution

Gastrointestinal

Gastrointestinal side effects have included vomiting.^[Ref]

Local

Local side effects have included burning, pain, inflammation, erosion, itching, and bleeding. Reports of burning and pain were greater and more severe in women than in men. Tenderness, chafing, malodor, scarring, vesicle formation, crusting edema, dryness, peeling, and ulceration have also been reported.^[Ref]

Genitourinary

Genitourinary side effects have included pain with intercourse, foreskin irretraction, and hematuria.^[Ref]

Nervous system

Nervous system side effects have included headache, insomnia, and dizziness.^[Ref]

It is possible that some side effects of podofilox topical may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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