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Pazeo Side Effects

Generic Name: olopatadine ophthalmic

Note: This document contains side effect information about olopatadine ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Pazeo.

For the Consumer

Applies to olopatadine ophthalmic: ophthalmic solution

Along with its needed effects, olopatadine ophthalmic (the active ingredient contained in Pazeo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking olopatadine ophthalmic:

Less common
  • Blurred vision
  • eye irritation or pain
  • swelling of the eyelid

Some side effects of olopatadine ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Less common
  • Back pain
  • body aches or pain
  • burning, dryness, itching, or stinging of the eye
  • change in taste
  • chills
  • cough
  • diarrhea
  • feeling of something in the eye
  • general feeling of discomfort or illness
  • increased cough
  • lack or loss of strength
  • loss of appetite
  • muscle aches and pains
  • nausea
  • pain or tenderness around the eyes and cheekbones
  • redness of the eye or inside of the eyelid
  • sensitivity of the eyes to light
  • shivering
  • sneezing
  • sweating
  • tender, swollen glands in the neck
  • trouble sleeping
  • trouble swallowing
  • unusual tiredness or weakness
  • voice changes
  • vomiting

For Healthcare Professionals

Applies to olopatadine ophthalmic: ophthalmic solution


The most commonly reported side effects were headache, asthenia, blurred vision, burning or stinging, cold syndrome, dry eye, foreign body sensation, and hyperemia.[Ref]


Common (1% to 10%): Eye pain, eye irritation, dry eye, abnormal sensation in eyes
Uncommon (0.1% to 1%): Corneal erosion, corneal epithelium defect, corneal epithelium disorder, punctate keratitis, keratitis, corneal staining, eye discharge, photophobia, blurred vision, reduced visual acuity, blepharospasm, ocular discomfort, eye pruritus, conjunctival follicles, conjunctival disorder, foreign body sensation in eyes, increased lacrimation, erythema of eyelid, eyelid edema, eyelid disorder, ocular hyperemia
Rare (less than 0.1%): Cases of corneal calcification (in association with the use of phosphate containing eye drops in some patients with significantly damaged corneas)
Frequency not reported: Corneal edema, eye edema, eye swelling, conjunctivitis, mydriasis, visual disturbance, eyelid margin crusting[Ref]


Frequency not reported: Hypersensitivity, swelling face[Ref]

Nervous system

Common (1% to 10%): Headache, dysgeusia
Uncommon (0.1% to 1%): Dizziness, hypoesthesia
Frequency not reported: Somnolence[Ref]


Common (1% to 10%): Nasal dryness
Uncommon (0.1% to 1%): Rhinitis
Frequency not reported: Dyspnea, sinusitis, cold syndrome, pharyngitis[Ref]


Rare (less than 0.1%): Dry mouth
Frequency not reported: Nausea, vomiting[Ref]


Frequency not reported: Asthenia, malaise[Ref]


Uncommon (0.1% to 1%): Contact dermatitis, skin burning sensation, dry skin
Frequency not reported: Dermatitis, erythema[Ref]


1. "Product Information. Patanol (olopatadine ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of Pazeo may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.