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Pataday Once Daily Relief Side Effects

Generic name: olopatadine ophthalmic

Medically reviewed by Last updated on Mar 15, 2024.

Note: This document contains side effect information about olopatadine ophthalmic. Some dosage forms listed on this page may not apply to the brand name Pataday Once Daily Relief.

Applies to olopatadine ophthalmic: ophthalmic solution.

Serious side effects

Along with its needed effects, olopatadine ophthalmic (the active ingredient contained in Pataday Once Daily Relief) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking olopatadine ophthalmic:

Less common

Other side effects

Some side effects of olopatadine ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to olopatadine ophthalmic: ophthalmic solution.


The most commonly reported side effects were headache, asthenia, blurred vision, burning or stinging, cold syndrome, dry eye, foreign body sensation, and hyperemia.[Ref]


Common (1% to 10%): Eye pain, eye irritation, dry eye, abnormal sensation in eyes

Uncommon (0.1% to 1%): Corneal erosion, corneal epithelium defect, corneal epithelium disorder, punctate keratitis, keratitis, corneal staining, eye discharge, photophobia, blurred vision, reduced visual acuity, blepharospasm, ocular discomfort, eye pruritus, conjunctival follicles, conjunctival disorder, foreign body sensation in eyes, increased lacrimation, erythema of eyelid, eyelid edema, eyelid disorder, ocular hyperemia

Rare (less than 0.1%): Cases of corneal calcification (in association with the use of phosphate containing eye drops in some patients with significantly damaged corneas)

Frequency not reported: Corneal edema, eye edema, eye swelling, conjunctivitis, mydriasis, visual disturbance, eyelid margin crusting[Ref]


Frequency not reported: Hypersensitivity, swelling face[Ref]

Nervous system

Common (1% to 10%): Headache, dysgeusia

Uncommon (0.1% to 1%): Dizziness, hypoesthesia

Frequency not reported: Somnolence[Ref]


Common (1% to 10%): Nasal dryness

Uncommon (0.1% to 1%): Rhinitis

Frequency not reported: Dyspnea, sinusitis, cold syndrome, pharyngitis[Ref]


Rare (less than 0.1%): Dry mouth

Frequency not reported: Nausea, vomiting[Ref]


Frequency not reported: Asthenia, malaise[Ref]


Uncommon (0.1% to 1%): Contact dermatitis, skin burning sensation, dry skin

Frequency not reported: Dermatitis, erythema[Ref]


1. (2001) "Product Information. Patanol (olopatadine ophthalmic)." Alcon Laboratories Inc

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.