Skip to main content

Parathyroid hormone Side Effects

Medically reviewed by Last updated on Jun 2, 2023.

Applies to parathyroid hormone: parenteral powder for injection.



FDA approved a REMS for parathyroid hormone to ensure that the benefits outweigh the risks. The REMS may apply to one or more preparations of parathyroid hormone and consists of the following: elements to assure safe use and implementation system. See the FDA REMS page ([Web]).

Side effects include:

Paresthesia, hypocalcemia, headache, hypercalcemia, nausea, hypoesthesia, diarrhea, vomiting, arthralgia, hypercalciuria, extremity pain, upper respiratory tract infection, upper abdominal pain, sinusitis, decreased 25-hydroxycholecalciferol concentration, hypertension, facial hypoesthesia, neck pain.

For Healthcare Professionals

Applies to parathyroid hormone: subcutaneous powder for injection.


The more commonly reported adverse reactions have included paresthesia, hypocalcemia, headache, hypercalcemia, nausea, hypoesthesia, diarrhea, vomiting, arthralgia, hypercalciuria, and extremity pain.


Very common (10% or more): Hypocalcemia (27%), hypercalcemia (19%); hypercalciuria (11%)[Ref]

Hypocalcemia combines reported events of hypocalcemia and blood calcium decreased; hypercalciuria combines reported events of hypercalciuria and urine calcium increased; and hypercalcemia combines reported events of hypercalcemia and blood calcium increased.

During clinical trials, 3 patients receiving this drug required IV fluids to correct hypercalcemia. In the postmarketing period, seizures due to hypocalcemia have been reported. The risk of hypocalcemia increases when this drug is withdrawn.[Ref]

Nervous system

Very common (10% or more): Paresthesia (31%), headache (25%), hypoesthesia (14%)

Common (1% to 10%): Facial hypoesthesia

Postmarketing reports: Seizures due to hypocalcemia[Ref]


Postmarketing reports: Hypersensitivity reactions including anaphylaxis, dyspnea, angioedema, urticaria, rash


Common (1% to 10%): Hypertension[Ref]


Very common (10% or more): Nausea (18%), diarrhea (12%), vomiting (12%)

Common (1% to 10%): Upper abdominal pain[Ref]


Very common (10% or more): Arthralgia (11%), pain in extremity (10%)

Common (1% to 10%): Neck pain[Ref]


Common (1% to 10%): Immunogenicity[Ref]


Common (1% to 10%): Blood 25-hydroxycholecalciferol decreased[Ref]


Common (1% to 10%): Upper respiratory tract infection, sinusitis[Ref]


1. Product Information. Natpara (parathyroid hormone). NPS Pharmaceuticals. 2015.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.