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Parathyroid hormone Pregnancy and Breastfeeding Warnings

Parathyroid hormone is also known as: Natpara

Medically reviewed by Drugs.com. Last updated on Feb 8, 2019.

Parathyroid hormone Pregnancy Warnings

Benefit should outweigh risk

US FDA pregnancy category: C

Animal reproduction studies in pregnant rats administered this drug from organogenesis through lactation in doses of 100, 300, and 1000 mcg/kg/day have shown an increased incidence of morbidity associated with dehydration, broken palate, and palate injuries related to incisor misalignment, in pups whose mothers had received 100 mcg/day (10 times the 100 mcg/day clinical dose based on AUC) and entire stillborn litters in groups administered 300 mcg/kg/day (34 times the 100 mcg/day clinical dose based on AUC). There are no adequate and well-controlled studies in pregnant women.

There are no data on the effects of this drug on human fertility; animal data do not indicate impairment of fertility.

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

See references

Parathyroid hormone Breastfeeding Warnings

Mean parathyroid hormone concentrations in rat milk have been estimated to be 42 times lower than milk plasma concentrations; a dose of 1000 mcg/kg/day yielded a rat milk concentration of approximately 10 ng/mL.

Benefit should outweigh risk

Excreted into human milk: Unknown
Excreted into animal milk: Yes

Comments:
-The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for this drug and any potential adverse effects to the breastfed infant from the drug or from the underlying maternal condition.

See references

References for pregnancy information

  1. "Product Information. Natpara (parathyroid hormone)." NPS Pharmaceuticals, Bedminster, NJ.

References for breastfeeding information

  1. "Product Information. Natpara (parathyroid hormone)." NPS Pharmaceuticals, Bedminster, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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