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Parathyroid Hormone Dosage

Applies to the following strengths: 25 mcg/dose; 50 mcg/dose; 75 mcg/dose; 100 mcg/dose

Usual Adult Dose for Hypocalcemia

Prior to initiating therapy:

INITIAL dose: 50 mcg subcutaneously once a day
ADJUST dose in increments of 25 mcg every 4 weeks if serum calcium cannot be maintained above 8 mg/dL without an active form of vitamin D and/or calcium supplementation
MAINTENANCE dose: 25 to 100 mcg subcutaneously once a day


Use: An adjunct to calcium and vitamin D to control hypocalcemia in patients with hypoparathyroidism.

Renal Dose Adjustments

Mild to moderate renal impairment: No adjustment recommended
Severe renal impairment: Data not available

Liver Dose Adjustments

Mild to moderate hepatic impairment: No adjustment recommended
Severe hepatic impairment: Data not available

Dose Adjustments

Elderly: Use with caution; consider starting at the lower end of the dosing range

Doses Adjustments for Active Forms of Vitamin D and Calcium Supplements:
Serum Calcium Above the Upper Limit of Normal (10.6 mg/dL):

Serum Calcium Greater than 9 mg/dL but below 10.6 mg/dL:
Serum Calcium less than or equal to 9 mg/dL but above 8 mg/dL:
Serum Calcium lower than 8 mg/dL:
Continue to adjust doses as above until target serum calcium is within the lower half of the normal range, active vitamin D is discontinued, and calcium supplementation is sufficient to meet daily requirements

Interruption or Discontinuation of Therapy:


The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for parathyroid hormone. It includes elements to assure safe use, and an implementation system. For additional information:



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Missed dose: If a dose is missed, administer as soon as possible; additional calcium may be needed

Storage requirements:

Reconstitution/preparation techniques:



Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.