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Paclitaxel protein-bound Side Effects

Medically reviewed by Last updated on Dec 15, 2023.

Applies to paclitaxel protein-bound: intravenous powder for suspension.


Intravenous route (Powder for Suspension)

Severe MyelosuppressionDo not administer paclitaxel protein-bound particles therapy to patients with baseline neutrophil counts less than 1500 cells/mm(3).Monitor for neutropenia, which may be severe and result in infection or sepsis.Perform frequent complete blood cell counts on all patients receiving paclitaxel protein-bound particles.

Serious side effects

Along with its needed effects, paclitaxel protein-bound may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking paclitaxel protein-bound:

More common

Less common

Other side effects

Some side effects of paclitaxel protein-bound may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


For Healthcare Professionals

Applies to paclitaxel protein-bound: intravenous powder for injection.


Very common (10% or more): Alopecia (90%), rash

Common (1% to 10%): Nail disorder, pruritus, dry skin, erythema, nail pigmentation/discoloration, skin hyperpigmentation, onycholysis, nail changes

Uncommon (0.1% to 1%): Nail bed tenderness, urticaria, skin pain, photosensitivity reaction, pigmentation disorder, pruritic rash, skin disorder, hyperhidrosis, onychomadesis, erythematous rash, generalized rash, dermatitis, night sweats, maculopapular rash, vitiligo, hypotrichosis, nail discomfort, generalized pruritus, macular rash, papular rash, skin lesion, swollen face

Very rare (less than 0.01%): Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)[Ref]


Very common (10% or more): Neutropenia (up to 82%), anemia (up to 25%), leukopenia, thrombocytopenia, lymphopenia, bone marrow suppression

Common (1% to 10%): Febrile neutropenia

Rare (less than 0.1%): Pancytopenia[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy, neuropathy, hypoesthesia, paresthesia

Common (1% to 10%): Peripheral sensory neuropathy, headache, dysgeusia, dizziness, peripheral motor neuropathy, ataxia, sensory disturbance, somnolence

Uncommon (0.1% to 1%): Polyneuropathy, areflexia, dyskinesia, hyporeflexia, neuralgia, sensory loss, syncope, postural dizziness, neuropathic pain, tremor, abnormal gait[Ref]


Very common (10% or more): Abnormal ECG (60%) including abnormal ECG in patients with a normal baseline (35%)

Common (1% to 10%): Tachycardia, arrhythmia, supraventricular tachycardia, flushing, hot flushes, hypertension, lymphedema, peripheral edema, chest pain

Uncommon (0.1% to 1%): Hypotension, peripheral coldness, orthostatic hypotension, chest discomfort, increased blood pressure

Rare (less than 0.1%): Bradycardia, cardiac arrest, left ventricular dysfunction, congestive heart failure, atrioventricular block, thrombosis[Ref]


Very common (10% or more): Arthralgia/myalgia (44%)

Common (1% to 10%): Pain in extremity, bone pain, back pain, muscle cramps, limb pain, rigors

Uncommon (0.1% to 1%): Chest wall pain, muscular weakness, neck pain, groin pain, muscle spasms, musculoskeletal pain, flank pain, limb discomfort, muscle weakness[Ref]


Very common (10% or more): AST (SGOT) elevations (39%), alkaline phosphatase elevations (36%), gamma-glutamyl transpeptidase (GGT) elevations (14%) patients

Common (1% to 10%): Bilirubin elevations

Uncommon (0.1% to 1%): Hepatomegaly

Rare (less than 0.1%): Hepatic necrosis, hepatic encephalopathy[Ref]


Very common (10% or more): Nausea (30%), diarrhea (26%), vomiting (18%), constipation, stomatitis

Common (1% to 10%): Abdominal pain, abdominal distension, upper abdominal pain, dyspepsia, gastroesophageal reflux disease, oral hypoesthesia, mucosal inflammation

Uncommon (0.1% to 1%): Dysphagia, flatulence, glossodynia, dry mouth, gingival pain, esophagitis, lower abdominal pain, mouth ulceration, oral pain, rectal hemorrhage

Rare (less than 0.1%): Intestinal obstruction, intestinal perforation, pancreatitis, ischemic colitis, neutropenic enterocolitis[Ref]


Very common (10% or more): Fatigue, asthenia, pyrexia

Common (1% to 10%): Vertigo, pain, edema, weakness, decreased performance status, malaise, lethargy, hyperpyrexia

Uncommon (0.1% to 1%): Ear pain, tinnitus[Ref]


Common (1% to 10%): Upper respiratory tract infection, sinusitis, interstitial pneumonitis, dyspnea, epistaxis, pharyngolaryngeal pain, cough, rhinitis, rhinorrhea

Uncommon (0.1% to 1%): Nasopharyngitis, pneumonia, productive cough, exertional dyspnea, sinus congestion, decreased breath sounds, pleural effusion, allergic rhinitis, hoarseness, nasal congestion, nasal dryness, wheezing, pulmonary emboli, pulmonary thromboembolism[Ref]


Very common (10% or more): Hypersensitivity (up to 12%)

Rare (less than 0.1%): Severe hypersensitivity[Ref]


Uncommon (0.1% to 1%): Swelling, injection site reaction

Rare (0.01% to 0.1%): Extravasation[Ref]


Common (1% to 10%): Increased lacrimation, blurred vision, dry eye, keratoconjunctivitis sicca, madarosis

Uncommon (0.1% to 1%): Eye irritation, eye pain, abnormal vision, reduced visual acuity, conjunctivitis, visual disturbance, eye pruritus, keratitis

Rare (less than 0.1%): Cystoid macular edema[Ref]


Common (1% to 10%): Urinary tract infection

Uncommon (0.1% to 1%): Dysuria, pollakiuria, hematuria, nocturia, polyuria, urinary incontinence, breast pain[Ref]


Very common (10% or more): Anorexia

Common (1% to 10%): Dehydration, hypokalemia, weight loss, increased alanine aminotransferase, increased aspartate aminotransferase, increased gamma-glutamyltransferase, decreased hematocrit, decreased red blood cell count, increased blood alkaline phosphatase

Uncommon (0.1% to 1%): Hypophosphatasemia, fluid retention, hypoalbuminemia, polydipsia, hyperglycemia, hypocalcemia, hypoglycemia, hyponatremia, weight gain, increased blood lactate dehydrogenase, increased blood creatinine, increased blood glucose, increased blood phosphorus, decreased blood potassium, increased bilirubin[Ref]


Uncommon (0.1% to 1%): Metastatic pain, tumor necrosis[Ref]


Common (1% to 10%): Insomnia, depression, anxiety

Uncommon (0.1% to 1%): Restlessness[Ref]


Very common (10% or more): Infections (up to 24%)

Common (1% to 10%): Febrile neutropenia, folliculitis, candidiasis, influenza-like illness

Uncommon (0.1% to 1%): Neutropenic sepsis, oral candidiasis, cellulitis, herpes simplex, viral infection, catheter-related infection, fungal infection, herpes zoster, injection site infection, sepsis, neutropenic sepsis[Ref]


1. Product Information. Abraxane (PACLitaxel protein-bound). American Pharmaceutical Partners. PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.