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Oxymorphone Side Effects

For the Consumer

Applies to oxymorphone: oral tablet, oral tablet extended release

Other dosage forms:

As well as its needed effects, oxymorphone may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking oxymorphone, check with your doctor immediately:

Less common:
  • Blurred vision
  • confusion
  • decreased urination
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fast, pounding, racing, or irregular heartbeat or pulse
  • headache
  • nervousness
  • pounding in the ears
  • rapid breathing
  • sunken eyes
  • sweating
  • swelling of the hands, ankles, or feet
  • thirst
  • tightness in the chest
  • unusual tiredness or weakness
  • wrinkled skin
  • Abdominal or stomach pain
  • chest pain or discomfort
  • chills
  • cold sweats
  • cough
  • decrease in consciousness
  • decrease in urine volume
  • difficulty in passing urine (dribbling)
  • difficulty with sleeping
  • difficulty with swallowing
  • disorientation
  • drowsiness to profound coma
  • fever
  • hallucination
  • hives, itching, or skin rash
  • hyperventilation
  • hoarseness
  • irregular, slow, or shallow breathing
  • irritability
  • irritation
  • joint pain, stiffness, or swelling
  • lethargy
  • painful urination
  • pale or blue lips, fingernails, or skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • restlessness
  • severe constipation
  • severe vomiting
  • shaking
  • trouble in holding or releasing urine

If any of the following symptoms of overdose occur while taking oxymorphone, get emergency help immediately:

Symptoms of overdose:
  • Cold and clammy skin
  • constricted, pinpoint, or small pupils (black part of the eye)
  • decreased awareness or responsiveness
  • low blood pressure or pulse
  • muscle weakness
  • severe sleepiness or unusual drowsiness
  • very slow breathing

Minor Side Effects

Some oxymorphone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Difficulty having a bowel movement (stool)
  • feeling of constant movement of self or surroundings
  • increased sweating
  • nausea or vomiting
  • relaxed and calm
  • sensation of spinning
  • sleepiness
Less common:
  • Acid or sour stomach
  • belching
  • decreased appetite
  • decreased weight
  • diarrhea
  • discouragement
  • excess air or gas in the stomach or intestines
  • feeling of warmth
  • feeling sad or empty
  • full or bloated feeling
  • heartburn
  • indigestion
  • lack of appetite
  • loss of interest or pleasure
  • passing gas
  • pressure in the stomach
  • redness of the face, neck, arms, and occasionally, upper chest
  • stomach discomfort or upset
  • swelling of the abdominal or stomach area
  • tiredness
  • trouble concentrating
  • Blistering, crusting, irritation, itching, or reddening of the skin
  • cracked, dry, scaly skin
  • difficulty with thinking or concentrating
  • disturbed color perception
  • double vision
  • false or unusual sense of well-being
  • feeling jittery
  • halos around lights
  • loss of vision
  • mental depression
  • night blindness
  • nightmares or unusually vivid dreams
  • overbright appearance of lights
  • sudden sweating
  • tunnel vision
  • welts

For Healthcare Professionals

Applies to oxymorphone: injectable solution, oral tablet, oral tablet extended release, rectal suppository


The most commonly reported adverse reactions included nausea, pyrexia, somnolence, vomiting, pruritus, headache, dizziness, constipation, and confusion. Additionally, the following adverse events were reported with the extended release tablet, diarrhea, insomnia, fatigue, decreased appetite and abdominal pain.[Ref]


Very common (10% or more): Constipation (up to 26%), nausea (up to 33%), vomiting (up to 16%)
Common (1% to 10%): Dry mouth, abdominal distention, flatulence, abdominal pain, diarrhea, dyspepsia
Frequency not reported: Paralytic ileus, ileus
Postmarketing reports: Difficulty swallowing tablets[Ref]


Common (1% to 10%): Hypoxia, dyspnea
Frequency not reported: Respiratory depression, atelectasis, bronchospasm, decreased oxygen saturation, respiratory distress, respiratory rate decreased
laryngospasm, laryngeal edema, apnea[Ref]

Nervous system

Very common (10% or more): Somnolence (up to 19%), dizziness (excluding vertigo; up to 18%)
Common (1% to 10%): Headache, confusion
Frequency not reported: Sedation, CNS depression
Postmarketing reports: Amnesia, convulsion, memory impairment[Ref]


Frequency not reported: Hypersensitivity including dermatitis allergic, urticaria, pruritus, face swelling[Ref]


Common (1% to 10%): Tachycardia, hypotension, edema, flushing, hypertension
Frequency not reported: Bradycardia, palpitations, orthostatic hypotension, syncope[Ref]


Common (1% to 10%): Anxiety, insomnia, confusion, disorientation, restlessness, nervousness, depression
Frequency not reported: Mental impairment, dysphoria, euphoric mood, agitation, hallucination, drug dependence, drug abuse, feeling jittery[Ref]


Frequency not reported: Ureteral spasm, urinary hesitation, urinary retention, oliguria, difficult micturition[Ref]


Very common (10% or more): Pruritus (up to 15%)
Common (1% to 10%): Increased sweating
Frequency not reported: Dermatitis[Ref]


Common (1% to 10%): Decreased appetite, dehydration, decreased weight
Frequency not reported: Anorexia[Ref]


Frequency not reported: Biliary colic[Ref]


Very common (10% or more): Pyrexia (14%)
Frequency not reported: Fatigue, asthenia, hot flashes, clamminess, weakness[Ref]


Common (1% to 10%): Vision blurred
Frequency not reported: Miosis, diplopia, visual disturbances[Ref]


Frequency not reported: Injection site reaction[Ref]


1. "Product Information. Opana ER (oxymorphone)." Endo Laboratories LLC, Chadds Ford, PA.

2. "Product Information. Opana (oxymorphone)." Endo Laboratories LLC, Chadds Ford, PA.

It is possible that some side effects of oxymorphone may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.