Skip to Content

Oxymorphone Side Effects

In Summary

Commonly reported side effects of oxymorphone include: constipation, dizziness, drowsiness, fever, headache, nausea, pruritus, and vomiting. Other side effects include: insomnia, diarrhea, xerostomia, and diaphoresis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to oxymorphone: oral tablet, oral tablet extended release

Other dosage forms:

Along with its needed effects, oxymorphone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oxymorphone:

Less Common

  • Blurred vision
  • confusion
  • decreased urination
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fast, pounding, racing, or irregular heartbeat or pulse
  • headache
  • nervousness
  • pounding in the ears
  • rapid breathing
  • sunken eyes
  • sweating
  • swelling of the hands, ankles, or feet
  • thirst
  • tightness in the chest
  • unusual tiredness or weakness
  • wrinkled skin


  • Abdominal or stomach pain
  • chest pain or discomfort
  • chills
  • cold sweats
  • cough
  • decrease in consciousness
  • decrease in urine volume
  • difficulty in passing urine (dribbling)
  • difficulty with sleeping
  • difficulty with swallowing
  • disorientation
  • drowsiness to profound coma
  • fever
  • hallucination
  • hives, itching, or skin rash
  • hyperventilation
  • hoarseness
  • irregular, slow, or shallow breathing
  • irritability
  • irritation
  • joint pain, stiffness, or swelling
  • lethargy
  • painful urination
  • pale or blue lips, fingernails, or skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • restlessness
  • severe constipation
  • severe vomiting
  • shaking
  • trouble in holding or releasing urine

Get emergency help immediately if any of the following symptoms of overdose occur while taking oxymorphone:

Symptoms of Overdose

  • Cold and clammy skin
  • constricted, pinpoint, or small pupils (black part of the eye)
  • decreased awareness or responsiveness
  • low blood pressure or pulse
  • muscle weakness
  • severe sleepiness or unusual drowsiness
  • very slow breathing

Some side effects of oxymorphone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Difficulty having a bowel movement (stool)
  • feeling of constant movement of self or surroundings
  • increased sweating
  • nausea or vomiting
  • relaxed and calm
  • sensation of spinning
  • sleepiness

Less Common

  • Acid or sour stomach
  • belching
  • decreased appetite
  • decreased weight
  • diarrhea
  • discouragement
  • excess air or gas in the stomach or intestines
  • feeling of warmth
  • feeling sad or empty
  • full or bloated feeling
  • heartburn
  • indigestion
  • lack of appetite
  • loss of interest or pleasure
  • passing gas
  • pressure in the stomach
  • redness of the face, neck, arms, and occasionally, upper chest
  • stomach discomfort or upset
  • swelling of the abdominal or stomach area
  • tiredness
  • trouble concentrating


  • Blistering, crusting, irritation, itching, or reddening of the skin
  • cracked, dry, scaly skin
  • difficulty with thinking or concentrating
  • disturbed color perception
  • double vision
  • false or unusual sense of well-being
  • feeling jittery
  • halos around lights
  • loss of vision
  • mental depression
  • night blindness
  • nightmares or unusually vivid dreams
  • overbright appearance of lights
  • sudden sweating
  • tunnel vision
  • welts

For Healthcare Professionals

Applies to oxymorphone: injectable solution, oral tablet, oral tablet extended release, rectal suppository


The most commonly reported adverse reactions included nausea, pyrexia, somnolence, vomiting, pruritus, headache, dizziness, constipation, and confusion. Additionally, the following adverse events were reported with the extended release tablet, diarrhea, insomnia, fatigue, decreased appetite and abdominal pain.[Ref]


Very common (10% or more): Constipation (up to 26%), nausea (up to 33%), vomiting (up to 16%)

Common (1% to 10%): Dry mouth, abdominal distention, flatulence, abdominal pain, diarrhea, dyspepsia

Frequency not reported: Paralytic ileus, ileus

Postmarketing reports: Difficulty swallowing tablets[Ref]


Common (1% to 10%): Hypoxia, dyspnea

Frequency not reported: Respiratory depression, atelectasis, bronchospasm, decreased oxygen saturation, respiratory distress, respiratory rate decreased

laryngospasm, laryngeal edema, apnea[Ref]

Nervous system

Very common (10% or more): Somnolence (up to 19%), dizziness (excluding vertigo; up to 18%)

Common (1% to 10%): Headache, confusion

Frequency not reported: Sedation, CNS depression

Postmarketing reports: Amnesia, convulsion, memory impairment[Ref]


Frequency not reported: Hypersensitivity including dermatitis allergic, urticaria, pruritus, face swelling[Ref]


Common (1% to 10%): Tachycardia, hypotension, edema, flushing, hypertension

Frequency not reported: Bradycardia, palpitations, orthostatic hypotension, syncope[Ref]


Common (1% to 10%): Anxiety, insomnia, confusion, disorientation, restlessness, nervousness, depression

Frequency not reported: Mental impairment, dysphoria, euphoric mood, agitation, hallucination, drug dependence, drug abuse, feeling jittery[Ref]


Frequency not reported: Ureteral spasm, urinary hesitation, urinary retention, oliguria, difficult micturition[Ref]


Very common (10% or more): Pruritus (up to 15%)

Common (1% to 10%): Increased sweating

Frequency not reported: Dermatitis[Ref]


Common (1% to 10%): Decreased appetite, dehydration, decreased weight

Frequency not reported: Anorexia[Ref]


Frequency not reported: Biliary colic[Ref]


Very common (10% or more): Pyrexia (14%)

Frequency not reported: Fatigue, asthenia, hot flashes, clamminess, weakness[Ref]


Common (1% to 10%): Vision blurred

Frequency not reported: Miosis, diplopia, visual disturbances[Ref]


Frequency not reported: Injection site reaction[Ref]


1. "Product Information. Opana ER (oxymorphone)." Endo Laboratories LLC, Chadds Ford, PA.

2. "Product Information. Opana (oxymorphone)." Endo Laboratories LLC, Chadds Ford, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.