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Oxymorphone

Generic Name: oxymorphone (OX ee MOR fone)
Brand Name: Opana, Opana ER, Numorphan HCl

Medically reviewed by Drugs.com on Oct 12, 2018 – Written by Cerner Multum

What is oxymorphone?

Oxymorphone is an opioid medication used to treat moderate to severe pain.

The extended-release form of oxymorphone is for around-the-clock treatment of pain and should not be used on an as-needed basis for pain.

Oxymorphone may also be used for purposes not listed in this medication guide.

Important Information

MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Before taking this medicine

You should not take oxymorphone if you are allergic to oxymorphone, or if you have:

  • severe asthma or breathing problems; or

  • a blockage in your stomach or intestines.

Tell your doctor if you have ever had:

  • a head injury or seizures;

  • drug or alcohol addiction, or mental illness;

  • urination problems;

  • liver or kidney problems; or

  • problems with your gallbladder, pancreas, or thyroid.

If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.

Do not breast-feed while taking oxymorphone.

How should I use oxymorphone?

Follow the directions on your prescription label and read all medication guides. Never use oxymorphone in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of this medicine.

Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.

Always check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.

Stop taking all other around-the-clock narcotic pain medications when you start taking oxymorphone.

Take oxymorphone on an empty stomach, at least 1 hour before or 2 hours after a meal.

Swallow the tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, or dissolve.

Never crush or break an oxymorphone pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This can cause in death.

Do not stop using this medicine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using oxymorphone.

Store at room temperature away from moisture, heat, and light. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.

What happens if I miss a dose?

Since oxymorphone is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A oxymorphone overdose can be fatal, especially in a child or other person using the medicine without a prescription.

Overdose symptoms may include extreme drowsiness, muscle weakness, confusion, cold and clammy skin, pinpoint pupils, slow heart rate, very slow breathing, or coma.

What should I avoid while using oxymorphone?

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how oxymorphone will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Oxymorphone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

  • weak or shallow breathing;

  • a light-headed feeling, like you might pass out;

  • seizure (convulsions);

  • chest pain, wheezing, cough with yellow or green mucus;

  • severe vomiting; or

  • low cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are malnourished or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect oxymorphone?

Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

This list is not complete. Other drugs may affect oxymorphone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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