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Opicapone Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Oct 30, 2023.

Applies to opicapone: oral capsule.

Serious side effects of Opicapone

Along with its needed effects, opicapone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking opicapone:

More common

Less common

Other side effects of Opicapone

Some side effects of opicapone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to opicapone: oral capsule.


The most commonly reported adverse reaction was dyskinesia.[Ref]

Nervous system

Very common (10% or more): Dyskinesia (17.7%)

Common (1% to 10%): Dizziness, headache, somnolence

Uncommon (0.1% to 1%): Dysgeusia, hyperkinesia, syncope

Postmarketing reports: Balance disorder, hyperkinesia tremor[Ref]


Common (1% to 10%): Abnormal dreams, hallucination, visual hallucination, insomnia

Uncommon (0.1% to 1%): Anxiety, depression, auditory hallucination, nightmares, sleep disorder

Postmarketing reports: Agitation, psychotic disorder, confusional state[Ref]


Common (1% to 10%): Orthostatic hypotension

Uncommon (0.1% to 1%): Palpitations, hypertension, hypotension[Ref]


Common (1% to 10%): Constipation, dry mouth, vomiting

Uncommon (0.1% to 1%): Abdominal distention, abdominal pain, upper abdominal pain, dyspepsia

Postmarketing reports: Diarrhea, nausea[Ref]


Uncommon (0.1% to 1%): Decreased appetite, hypertriglyceridemia, decreased weight[Ref]


Uncommon (0.1% to 1%): Dyspnea[Ref]


Uncommon (0.1% to 1%): Chromaturia, nocturia[Ref]


Common (1% to 10%): Muscle spasms

Uncommon (0.1% to 1%): Muscle twitching, musculoskeletal stiffness, myalgia, extremity pain[Ref]


Uncommon (0.1% to 1%): Dry eye


Common (1% to 10%): Blood creatine phosphokinase increased

Uncommon (0.1% to 1%): Ear congestion

Postmarketing reports: Fatigue, malaise[Ref]


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Product Information. Ongentys (opicapone). Neurocrine Biosciences, Inc. 2020.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.