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Opicapone Dosage

Medically reviewed by Last updated on Jul 24, 2023.

Applies to the following strengths: 25 mg; 50 mg

Usual Adult Dose for Parkinson's Disease

50 mg orally once a day at bedtime

Use: As adjunctive treatment to levodopa/carbidopa in patients with Parkinson's disease (PD) experiencing "off" episodes

Renal Dose Adjustments

Mild/moderate renal impairment: No adjustment recommended
Severe renal impairment: Monitor for adverse reactions and discontinue if tolerability issues arise
End stage (CrCl less than 15 mL/min) renal impairment: Use should be avoided

Liver Dose Adjustments

Mild hepatic impairment (Child-Pugh A): No adjustment recommended
Moderate hepatic impairment (Child-Pugh B): 25 mg orally once daily at bedtime
Severe hepatic impairment (Child-Pugh C): Use should be avoided

Dose Adjustments


Drug discontinuation:



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

MISSED DOSE: If a dose is missed, take the next dose at the scheduled time the next day

Storage requirements:



Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.