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Onivyde Side Effects

Generic Name: irinotecan liposomal

Note: This document contains side effect information about irinotecan liposomal. Some of the dosage forms listed on this page may not apply to the brand name Onivyde.

In Summary

Common side effects of Onivyde include: fever. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to irinotecan liposomal: intravenous solution

Along with its needed effects, irinotecan liposomal (the active ingredient contained in Onivyde) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking irinotecan liposomal:

More Common

  • Confusion
  • decreased urination
  • diarrhea (severe)
  • dizziness
  • dry mouth
  • fainting
  • fever
  • lightheadedness
  • rapid breathing
  • sunken eyes
  • thirst
  • unusual tiredness or weakness
  • wrinkled skin

Less Common

  • Black, tarry stools
  • chest pain or discomfort
  • chills
  • confusion
  • cough
  • fast heartbeat
  • lightheadedness, dizziness, or fainting
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • rapid, shallow breathing
  • shortness of breath
  • slow or irregular heartbeat
  • sore throat
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising

Incidence Not Known

  • Difficulty with breathing or swallowing
  • hives, itching, or skin rash
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • reddening of the skin, especially around the ears
  • tightness in the chest

Some side effects of irinotecan liposomal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

  • Abdominal or stomach pain
  • feeling of warmth
  • increased sweating
  • runny nose
  • sneezing
  • stuffy nose
  • tearing of the eyes
  • watering of the mouth
  • weakness

For Healthcare Professionals

Applies to irinotecan liposomal: intravenous dispersion


Very common (10% or more): Diarrhea (59%), vomiting (52%), nausea (51%), stomatitis (32%)

Common (1% to 10%): Gastroenteritis[Ref]


Very common (10% or more): Alopecia (14%)[Ref]


The most common (2% or more) serious adverse reactions were diarrhea, vomiting, neutropenic fever or neutropenic sepsis, nausea, pyrexia, sepsis, dehydration, septic shock, pneumonia, acute renal failure, and thrombocytopenia.[Ref]


Very common (10% or more): Anemia (97%), lymphopenia (81%), neutropenia (52%), thrombocytopenia (41%)

Common (1% to 10%): Neutropenic fever/neutropenic sepsis[Ref]


Very common (10% or more): Increased ALT (51%), hypoalbuminemia (43%)[Ref]


Common (1% to 10%): Infusion reaction (rash, urticaria, periorbital edema, pruritus)[Ref]


Very common (10% or more): Decreased appetite (44%), hypomagnesemia (35%), hypocalcemia (32%), hypokalemia (32%), hypophosphatemia (29%), hyponatremia (27%), weight loss (17%)

Common (1% to 10%): Dehydration[Ref]

Nervous system

Common (1% to 10%): Cholinergic reactions[Ref]


Very common (10% or more): Fatigue/asthenia (56%), pyrexia (23%)

Common (1% to 10%): IV catheter-related infection, sepsis[Ref]


Very common (10% or more): Increased creatinine (18%)[Ref]


1. "Product Information. Onivyde (irinotecan liposomal)." Merrimack Pharmaceuticals, Cambridge, MA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.