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Omontys Side Effects

Generic Name: peginesatide

Note: This document contains side effect information about peginesatide. Some of the dosage forms listed on this page may not apply to the brand name Omontys.

For the Consumer

Applies to peginesatide: injection solution

Along with its needed effects, peginesatide (the active ingredient contained in Omontys) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking peginesatide:

More Common

  • Abdominal or stomach pain
  • blurred vision
  • body aches or pain
  • chills
  • confusion
  • cough
  • difficulty with breathing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • ear congestion
  • fever
  • headache
  • irregular heartbeat
  • loss of voice
  • nasal congestion
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pounding in the ears
  • runny nose
  • shortness of breath
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • sweating
  • unusual tiredness or weakness
  • weakness or heaviness of the legs

Incidence Not Known

  • Back pain
  • chest tightness
  • chills
  • difficulty with swallowing
  • flushing
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • skin rash
  • trouble breathing
  • weakness

Some side effects of peginesatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Diarrhea
  • difficulty with moving
  • muscle pain or stiffness
  • muscle spasms
  • pain in the arms or legs
  • pain in the joints

For Healthcare Professionals

Applies to peginesatide: injectable solution


Cardiovascular side effects have included hypotension (14.2%), hypertension (13.2%), and procedural hypotension (10.9%).[Ref]


Gastrointestinal side effects have included diarrhea (18.4%), nausea (17.4%), and vomiting (15.3%).[Ref]


General side effects have included pyrexia (12.2%).[Ref]


Immunologic side effects have included the development of peginesatide (the active ingredient contained in Omontys) specific antibodies (1.2%).[Ref]


Metabolic side effects have included hyperkalemia (11.4%).[Ref]


Musculoskeletal side effects have included muscle spasms (15.3%), pain in extremity (10.9%), back pain (10.9%), and arthralgia (10.7%).[Ref]

Nervous system

Nervous system side effects have included headache (15.4%).[Ref]


Other side effects have included arteriovenous fistula site complication (16.1%).[Ref]


Respiratory side effects have included dyspnea (18.4%), cough (15.9%), and upper respiratory infection (11.0%).[Ref]


Hypersensitivity side effects have included postmarketing reports of serious allergic reactions including fatal reactions (0.02%).


1. "Product Information. Omontys (peginesatide)." Takeda Pharmaceuticals America, Lincolnshire, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.