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Olinvyk Side Effects

Generic name: oliceridine

Medically reviewed by Drugs.com. Last updated on Aug 11, 2022.

Note: This document contains side effect information about oliceridine. Some dosage forms listed on this page may not apply to the brand name Olinvyk.

Applies to oliceridine: intravenous solution.

Warning

Intravenous route (Solution)

Warning: Addiction, abuse, and misuse; life-threatening respiratory depression; neonatal opioid withdrawal syndrome; and risks from concomitant use with benzodiazepines or other CNS depressantsOliceridine exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient's risk before prescribing, and monitor all patients regularly for the development of behaviors or conditions.Serious, life-threatening, or fatal respiratory depression may occur. Monitor for respiratory depression, especially during initiation or following a dose increase.Prolonged use of oliceridine during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available.Concomitant use of oliceridine with benzodiazepines or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing for use in patients for whom alternative treatment options are inadequate; limit dosages and durations to the minimum required; and follow patients for signs and symptoms of respiratory depression and sedation.

Serious side effects of Olinvyk

Along with its needed effects, oliceridine (the active ingredient contained in Olinvyk) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking oliceridine:

More common

Less common

  • Blurred vision
  • bone pain
  • chest tightness
  • difficult or labored breathing
  • dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • extremely shallow or slow breathing
  • fainting
  • fever
  • muscle spasms (tetany) or twitching seizures
  • numbness and tingling around the mouth, fingertips, or feet
  • pale skin
  • stomach cramps
  • sweating
  • trembling
  • tremor
  • unusual bleeding or bruising

Get emergency help immediately if any of the following symptoms of overdose occur while taking oliceridine:

Symptoms of overdose

  • Bigger, dilated, or enlarged pupils (black part of the eye)
  • chest pain or discomfort
  • cold and clammy skin
  • confusion
  • constricted pupils
  • coughing that sometimes produces a pink frothy sputum
  • increased sensitivity of the eyes to light
  • irregular, fast or slow, or shallow breathing
  • loss of consciousness
  • no muscle tone or movement
  • pale or blue lips, fingernails, or skin
  • slow heartbeat
  • swelling in the legs and ankles

Other side effects of Olinvyk

Some side effects of oliceridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to oliceridine: intravenous solution.

General

The most common adverse events were nausea, vomiting, dizziness, headache, constipation, pruritus, and hypoxia.[Ref]

Nervous system

Very common (10% or more): Dizziness (35%), somnolence (19%), sedation (14%)

Common (1% to 10%): Headache[Ref]

Respiratory

Common (1% to 10%): Hypoxia, oxygen saturation decreased, cough dyspnea[Ref]

Gastrointestinal

Very common (10% or more): Nausea (63%), vomiting (41%), constipation (14%)

Common (1% to 10%): Flatulence, dry mouth, dyspepsia, diarrhea[Ref]

Dermatologic

Very common (10% or more): Pruritus (15%)

Common (1% to 10%): Hyperhidrosis, rash, pruritus generalized[Ref]

Cardiovascular

Common (1% to 10%): Hot flush, tachycardia blood pressure increased, hypotension, flushing[Ref]

Local

Common (1% to 10%): Infusion site extravasation[Ref]

Hematologic

Common (1% to 10%): Anemia[Ref]

Metabolic

Common (1% to 10%): Hypokalemia, hypocalcemia, hypophosphatemia, hypomagnesemia[Ref]

Musculoskeletal

Very common (10% or more): Back pain (13%)

Common (1% to 10%): Muscle spasms[Ref]

Psychiatric

Common (1% to 10%): Anxiety, insomnia, restlessness[Ref]

Other

Common (1% to 10%): Pyrexia[Ref]

Hepatic

Common (1% to 10%): Alanine aminotransferase increased[Ref]

References

1. "Product Information. Olinvyk (oliceridine)." Trevena Inc (2020):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.