Olinvyk Side Effects

Generic name: oliceridine

Medically reviewed by Drugs.com. Last updated on Apr 11, 2025.

Note: This document provides detailed information about Olinvyk Side Effects associated with oliceridine. Some dosage forms listed on this page may not apply specifically to the brand name Olinvyk.

Applies to oliceridine: intravenous solution.

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.

This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

Symptoms of an overdose include: extreme dizziness or weakness, slow heartbeat or breathing, seizures, trouble breathing, or cold, clammy skin. Tell your doctor right away if you notice these symptoms.

This medicine may cause sleep-related breathing problems (eg, sleep apnea, sleep-related hypoxemia). Your doctor may decrease your dose if you have sleep apnea (stop breathing for short periods during sleep) while receiving this medicine.

Receiving this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn babies. Tell your doctor right away if your baby has an abnormal sleep pattern, diarrhea, a high-pitched cry, irritability, shakiness or tremors, weight loss, vomiting, or fails to gain weight.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, other prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the other medicines listed above while you are receiving this medicine.

This medicine may cause adrenal gland problems. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, nausea, depression, skin rash, unusual tiredness or weakness, or vomiting.

Severe dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

This medicine may make you dizzy or less alert than you are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

If you have been receiving this medicine regularly for several days, do not suddenly stop receiving it without first checking with your doctor. You or your child may be directed to slowly reduce the amount you are using before stopping treatment completely to lessen the chance of withdrawal side effects (eg, stomach cramps, fever, runny nose, anxiety, or restlessness).

Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.

Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you or your child to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

Receiving too much of this medicine may cause infertility (unable to have children). Talk with your doctor before receiving this medicine if you plan to have children.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or non-prescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Olinvyk

Along with its needed effects, oliceridine (the active ingredient contained in Olinvyk) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking oliceridine:

Get emergency help immediately if any of the following symptoms of overdose occur while taking oliceridine:

Symptoms of overdose

• bigger, dilated, or enlarged pupils (black part of the eye)
• chest pain or discomfort
• cold and clammy skin
• confusion
• constricted pupils
• coughing that sometimes produces a pink frothy sputum
• increased sensitivity of the eyes to light
• irregular, fast or slow, or shallow breathing
• loss of consciousness
• no muscle tone or movement
• pale or blue lips, fingernails, or skin
• slow heartbeat
• swelling in the legs and ankles

Other side effects of Olinvyk

Some side effects of oliceridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to oliceridine: intravenous solution.

General adverse events

The most common adverse events were nausea, vomiting, dizziness, headache, constipation, pruritus, and hypoxia.^[Ref]

Nervous system

• Very common (10% or more): Dizziness (35%), somnolence (19%), sedation (14%)
• Common (1% to 10%): Headache^[Ref]

Respiratory

• Common (1% to 10%): Hypoxia, oxygen saturation decreased, cough dyspnea^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (63%), vomiting (41%), constipation (14%)
• Common (1% to 10%): Flatulence, dry mouth, dyspepsia, diarrhea^[Ref]

Dermatologic

• Very common (10% or more): Pruritus (15%)
• Common (1% to 10%): Hyperhidrosis, rash, pruritus generalized^[Ref]

Cardiovascular

• Common (1% to 10%): Hot flush, tachycardia blood pressure increased, hypotension, flushing^[Ref]

Local

• Common (1% to 10%): Infusion site extravasation^[Ref]

Hematologic

• Common (1% to 10%): Anemia^[Ref]

Metabolic

• Common (1% to 10%): Hypokalemia, hypocalcemia, hypophosphatemia, hypomagnesemia^[Ref]

Musculoskeletal

• Very common (10% or more): Back pain (13%)
• Common (1% to 10%): Muscle spasms^[Ref]

Psychiatric

• Common (1% to 10%): Anxiety, insomnia, restlessness^[Ref]

Other

• Common (1% to 10%): Pyrexia^[Ref]

Hepatic

• Common (1% to 10%): Alanine aminotransferase increased^[Ref]

See also:

Further information

Olinvyk side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer