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Nystop Side Effects

Generic Name: nystatin topical

Note: This page contains side effects data for the generic drug nystatin topical. It is possible that some of the dosage forms included below may not apply to the brand name Nystop.

For the Consumer

Applies to nystatin topical: vaginal cream, vaginal tablet

As well as its needed effects, nystatin topical (the active ingredient contained in Nystop) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking nystatin topical, check with your doctor or nurse as soon as possible:

  • Vaginal burning or itching not present before use of this medicine

For Healthcare Professionals

Applies to nystatin topical: topical cream, topical kit, topical ointment, topical powder, vaginal tablet


Dermatologic side effects associated with nystatin topical (the active ingredient contained in Nystop) powder, cream, and ointment have included skin irritation, burning, itching, rash, eczema, and pain on application in less than 0.1% of patients.[Ref]


Genitourinary side effects associated with nystatin vaginal tablets have included vaginal irritation, burning, and itching. At least one case of severe vulvovaginitis has also been reported.[Ref]

A 64-year-old female experienced severe vulvovaginitis while receiving intravaginal nystatin therapy for Candida glabrata infection. She was administered nystatin vaginal tablets, 100,000 units twice daily for 14 days. She returned immediately after having completed the course complaining of intense skin rash in the vulvar area accompanied by severe irritation, burning, and itching. Therapy with a hydrocortisone cream and intramuscular betamethasone dipropionate was initiated. A week later, she had marked improvement with clearing of the vulvovaginal erythema and edema.[Ref]


Hypersensitivity side effects associated with nystatin topical (the active ingredient contained in Nystop) powder, cream, and ointment have included allergic reactions and allergic contact dermatitis in less than 0.1% of patients. Stevens-Johnson syndrome has also been reported.


1. Wasilewski C Jr "Allergic contact dermatitis from nystatin." Arch Dermatol 102 (1970): 216-7

2. Quirce S, Parra F, Lazaro M, Gomez MI, Sanchez Cano M "Generalized dermatitis due to oral nystatin." Contact Dermatitis 25 (1991): 197-8

3. Garty BZ "Stevens-Johnson syndrome associated with nystatin treatment." Arch Dermatol 127 (1991): 741-2

4. "Product Information. Mycostatin Cream, Mycostatin Topical Powder (nystatin)." Westwood Squibb Pharmaceutical Corporation, Eatontown, NJ.

5. Lang E, Goos M "Combined allergy to tolnaftate and nystatin." Contact Dermatitis 12 (1985): 182

6. "Product Information. Mycostatin Pastilles (nystatin)." Ernest Jackson & Co., Ltd., Crediton, Devon, England, .

7. de Groot AC, Conemans JM "Nystatin allergy. Petrolatum is not the optimal vehicle for patch testing." Dermatol Clin 8 (1990): 153-5

8. Hills RJ, Ive FA "Contact sensitivity to nystatin in Timodine." Contact Dermatitis 28 (1993): 48

9. Wasilewski C Jr "Allergic contact dermatitis from nystatin." Arch Dermatol 104 (1971): 437

It is possible that some side effects of Nystop may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.