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Nitazoxanide Side Effects

Medically reviewed by Last updated on Aug 11, 2023.

Applies to nitazoxanide: oral powder for suspension, oral tablet.

Serious side effects of Nitazoxanide

Along with its needed effects, nitazoxanide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nitazoxanide:

Incidence not known

Other side effects of Nitazoxanide

Some side effects of nitazoxanide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Incidence not known

For Healthcare Professionals

Applies to nitazoxanide: oral powder for reconstitution, oral tablet.


Side effects were generally mild. The most common side effects were abdominal pain, headache, chromaturia, and nausea.[Ref]


Common (1% to 10%): Abdominal pain, nausea

Frequency not reported: Vomiting, flatulence, dyspepsia, constipation, dry mouth, enlarged salivary glands

Postmarketing reports: Diarrhea, gastroesophageal reflux disease[Ref]

Nervous system

Common (1% to 10%): Headache

Frequency not reported: Somnolence, tremor, hypesthesia, syncope

Postmarketing reports: Dizziness[Ref]


Common (1% to 10%): Chromaturia

Frequency not reported: Discolored urine, dysuria, amenorrhea, metrorrhagia, edema labia[Ref]


Frequency not reported: Pruritus, sweat

Postmarketing reports: Rash, urticaria[Ref]


Frequency not reported: Epistaxis, rhinitis, lung disease, pharyngitis

Postmarketing reports: Dyspnea[Ref]


Frequency not reported: Asthenia, fever, pain, pelvic pain, back pain, influenza syndrome, earache, chills, thirst, infection[Ref]


Frequency not reported: Anorexia, increased appetite[Ref]


Frequency not reported: Myalgia, leg cramps, spontaneous bone fracture[Ref]


Frequency not reported: Tachycardia, hypertension[Ref]


Frequency not reported: Anemia, leukocytosis[Ref]


Frequency not reported: Kidney pain, increased creatinine[Ref]


Frequency not reported: Insomnia[Ref]


Frequency not reported: Increased ALT[Ref]


Frequency not reported: Allergic reaction[Ref]


Frequency not reported: Eye discoloration (including pale yellow eye discoloration)[Ref]


1. Product Information. Alinia (nitazoxanide). Romark Laboratories L.C. 2002.

2. Melbourne: Therapeutic Guidelines Limited. eTG complete [Online] 2015.

3. Stockis A, De Bruyn S, Gengler C, Rosillon D. Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d. Int J Clin Pharmacol Ther. 2002;40:221-7.

4. Fox LM, Saravolatz LD. Nitazoxanide: a new thiazolide antiparasitic agent. Clin Infect Dis. 2005;40:1173-80.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.