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Nitazoxanide Side Effects

For the Consumer

Applies to nitazoxanide: oral powder for suspension, oral tablet

As well as its needed effects, nitazoxanide may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking nitazoxanide, check with your doctor immediately:

Incidence not known:
  • Diarrhea

Minor Side Effects

Some nitazoxanide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Abdominal or stomach pain
  • headache
  • nausea
  • urine changes
Incidence not known:
  • Dizziness
  • heartburn
  • hives or welts, itching, or skin rash
  • redness of the skin
  • trouble breathing
  • vomiting

For Healthcare Professionals

Applies to nitazoxanide: oral powder for reconstitution, oral tablet


Gastrointestinal side effects have included abdominal pain (6.6% to 7.8%), diarrhea (2.1% to 4.2%), and nausea (3%). Side effects occurring in less than 1% of patients have included vomiting, anorexia, flatulence, dyspepsia, constipation, dry mouth, and thirst.[Ref]

The incidence of gastrointestinal side effects may be dose related. Abdominal pain, diarrhea and discolored urine occurred more often in subjects receiving higher doses (1 gram twice daily).[Ref]

Nervous system

Nervous system side effects have included headache (3.1%). Dizziness, somnolence, insomnia, tremor, and hypesthesia have been reported by less than 1% of the patients.[Ref]


Adverse effects affecting the body as a whole have included asthenia, fever, pain (pelvic/back), flu syndrome, ear ache, and chills in less than 1% of patients.[Ref]


Metabolic side effects have included increased creatinine and SGPT in less than 1% of patients.[Ref]


Dermatologic side effects have included pruritus, rash, and sweat in less than 1% of patients.[Ref]


Ocular side effects have included pale yellow eye discoloration (<1%).[Ref]


Respiratory side effects have included epistaxis, rhinitis, lung disease, and pharyngitis.[Ref]


Genitourinary side effects have included discolored urine, dysuria, amenorrhea, metrorrhagia, and edema labia.[Ref]


In general, side effects have been mild and transient in nature. The most frequent side effects have included abdominal pain, diarrhea, vomiting, and headache, and the rates of occurrence were not significantly different from placebo.[Ref]


Musculoskeletal side effects have included myalgia, leg cramps, and spontaneous bone fracture.[Ref]


Cardiovascular side effects have included tachycardia, syncope, and hypertension.[Ref]


Hematologic side effects have included anemia and leukocytosis.[Ref]


Renal side effects have included kidney pain.[Ref]


1. "Product Information. Alinia (nitazoxanide)." Romark Laboratories L.C., Tampa, FL.

2. Fox LM, Saravolatz LD "Nitazoxanide: a new thiazolide antiparasitic agent." Clin Infect Dis 40 (2005): 1173-80

3. Stockis A, De Bruyn S, Gengler C, Rosillon D "Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d." Int J Clin Pharmacol Ther 40 (2002): 221-7

It is possible that some side effects of nitazoxanide may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.