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Nintedanib Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jun 22, 2023.

Applies to nintedanib: oral capsule.

Serious side effects of Nintedanib

Along with its needed effects, nintedanib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nintedanib:

More common

Less common

Incidence not known

Other side effects of Nintedanib

Some side effects of nintedanib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to nintedanib: oral capsule.


The most common side effects included diarrhea, nausea, abdominal pain, vomiting, liver enzyme elevation, decreased appetite, headache, weight decreased, hypertension, and peripheral neuropathy.[Ref]


Very common (10% or more): Diarrhea (62%), nausea (24%), abdominal pain (15%), vomiting (12%), constipation (12%), abdominal pain, mucositis (including stomatitis)

Uncommon (0.1% to 1%): Pancreatitis, GI perforation[Ref]


Common (1% to 10%): Hypertension, venous thromboembolism, myocardial infarction, chest pain

Uncommon (0.1% to 1%): Hypertension[Ref]


Very common (10% or more): Neutropenia (14%), hemoglobinemia (12%), bleeding events (10%)

Common (1% to 10%): Febrile neutropenia

Uncommon (0.1% to 1%): Thrombocytopenia[Ref]


Very common (10% or more): Liver enzyme elevation (14%)

Common (1% to 10%): Hyperbilirubinemia, alanine aminotransferase (ALT) increased, aspartate aminotransferase (AST) increased, gamma glutamyl transferase (GGT) increased

Uncommon (0.1% to 1%): Drug induced liver injury, hyperbilirubinemia, blood alkaline phosphatase (ALKP) increased[Ref]


Very common (10% or more): Alopecia (18%), rash[Ref]


Common (1% to 10%): Hypothyroidism[Ref]


Very common (10% or more): Decreased appetite (11%), weight loss (10%)

Common (1% to 10%): Dehydration

Frequency not reported: Electrolyte imbalance[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (19%)

Common (1% to 10%): Headache[Ref]


Frequency not reported: Lung neoplasm malignant[Ref]


Very common (10% or more): Fatigue (27%), pyrexia (15%)

Frequency not reported: Embryofetal toxicity[Ref]


Very common (10% or more): Nasopharyngitis (56%), bronchitis (11%), dyspnea (17%), cough (17%), idiopathic pulmonary fibrosis (10%)

Common (1% to 10%): Upper respiratory tract infection, pneumonia[Ref]


Common (1% to 10%): Abscesses, sepsis[Ref]


Common (1% to 10%): Back pain, arthralgia[Ref]

Frequently asked questions


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Product Information. Ofev (nintedanib). Boehringer Ingelheim. 2014.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.