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Nintedanib Dosage

Medically reviewed by Last updated on Jun 8, 2023.

Applies to the following strengths: 100 mg; 150 mg

Usual Adult Dose for Idiopathic Pulmonary Fibrosis

150 mg orally every 12 hours
Maximum dose: 300 mg/day



Usual Adult Dose for Chronic Lung Disease

150 mg orally every 12 hours
Maximum dose: 300 mg/day



Renal Dose Adjustments

Mild to Moderate Renal Dysfunction (CrCl 30 to 90 mL/min): No adjustment recommended.
Severe Renal Dysfunction (CrCl less than 30 mL/min): Data not available

Liver Dose Adjustments

Mild Liver Dysfunction (Child-Pugh A): 100 mg orally 2 times a day; consider interruption or discontinuation of therapy for management of adverse reactions
Moderate or Severe Liver Dysfunction (Child-Pugh B or C): Not recommended.

AST or ALT elevation between 3 to 5 times the upper limit of normal (ULN) without signs of liver damage:

Dose Adjustments

To manage severe side effects:



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Storage requirements:



Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.