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Necitumumab Side Effects

For the Consumer

Applies to necitumumab: intravenous solution

Along with its needed effects, necitumumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking necitumumab:

More common
  • Abdominal or stomach cramps
  • confusion
  • convulsions
  • decreased urine
  • difficulty with breathing
  • drowsiness
  • dry mouth
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood or mental changes
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle pain or muscle spasms (tetany) or twitching
  • nausea or vomiting
  • numbness and tingling around the mouth, fingertips, or feet
  • tremor
  • unusual tiredness or weakness
Less common
  • Anxiety
  • back pain
  • chest pain or discomfort
  • chest tightness
  • chills
  • cough
  • difficulty with speaking
  • dizziness or lightheadedness
  • double vision
  • fainting
  • fast heartbeat
  • fever
  • flushing
  • headache
  • heart stops
  • inability to move the arms, legs, or facial muscles
  • no breathing
  • no pulse or blood pressure
  • pain or discomfort in the arms, jaw, back, or neck
  • pain, redness, or swelling in the arm or leg
  • pains in the chest, groin, or legs, especially the calves of the legs
  • severe headaches of sudden onset
  • slow speech
  • sudden loss of coordination
  • sudden onset of slurred speech
  • sudden shortness of breath or troubled breathing
  • sudden vision changes
  • sweating
  • trouble breathing
  • unconscious

Some side effects of necitumumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Blemishes on the skin
  • burning, dry, or itching eyes
  • decreased weight
  • diarrhea
  • discharge or excessive tearing
  • dry skin
  • itching skin or rash
  • loosening of the fingernails
  • pimples
  • rash with flat lesions or small raised lesions on the skin
  • redness or soreness around the fingernails
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • swelling or inflammation of the mouth

For Healthcare Professionals

Applies to necitumumab: intravenous solution

Cardiovascular

Common (1% to 10%): Venous thromboembolic events (VTE)
Frequency not reported: Cardiopulmonary arrest[Ref]

Dermatologic

Very common (10% or more): Rash (44%), dermatitis acneiform (15%)
Common (1% to 10%): Acne, pruritus, dry skin, skin fissures[Ref]

Gastrointestinal

Very common (10% or more): Vomiting (29%), diarrhea (16%), stomatitis (11%)[Ref]

Local

Frequency not reported: Infusion related reactions[Ref]

Metabolic

Very common (10% or more): Hypomagnesemia (83%), hypocalcemia (45%), hypocalcemia (albumin corrected) (36%), hypophosphatemia (31%), hypokalemia (28%), weight loss (13%)[Ref]

Nervous system

Very common (10% or more): Headache (11%)[Ref]

Ocular

Common (1% to 10%): Conjunctivitis (includes conjunctivitis, eye irritation, vision blurred, conjunctivitis bacterial, dry eye, visual acuity reduced, blepharitis, allergic blepharitis, conjunctiva hemorrhage, eye infection, eye pain, lacrimation increased, ocular hyperemia, Sjogren's syndrome, visual impairment, and eye pruritus)[Ref]

Oncologic

Frequency not reported: Non-Squamous NSCLC -increased toxicity and increased mortality[Ref]

Respiratory

Common (1% to 10%): Hemoptysis, pulmonary embolism[Ref]

References

1. "Product Information. Portrazza (necitumumab)." Eli Lilly and Company, Indianapolis, IN.

Some side effects of necitumumab may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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