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Necitumumab Side Effects

For the Consumer

Applies to necitumumab: intravenous solution

As well as its needed effects, necitumumab may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking necitumumab, check with your doctor or nurse immediately:

More common:
  • Abdominal or stomach cramps
  • confusion
  • convulsions
  • decreased urine
  • difficulty with breathing
  • drowsiness
  • dry mouth
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood or mental changes
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle pain or muscle spasms (tetany) or twitching
  • nausea or vomiting
  • numbness and tingling around the mouth, fingertips, or feet
  • tremor
  • unusual tiredness or weakness
Less common:
  • Anxiety
  • back pain
  • chest pain or discomfort
  • chest tightness
  • chills
  • cough
  • difficulty with speaking
  • dizziness or lightheadedness
  • double vision
  • fainting
  • fast heartbeat
  • fever
  • flushing
  • headache
  • heart stops
  • inability to move the arms, legs, or facial muscles
  • no breathing
  • no pulse or blood pressure
  • pain or discomfort in the arms, jaw, back, or neck
  • pain, redness, or swelling in the arm or leg
  • pains in the chest, groin, or legs, especially the calves of the legs
  • severe headaches of sudden onset
  • slow speech
  • sudden loss of coordination
  • sudden onset of slurred speech
  • sudden shortness of breath or troubled breathing
  • sudden vision changes
  • sweating
  • trouble breathing
  • unconscious

Minor Side Effects

Some necitumumab side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Blemishes on the skin
  • burning, dry, or itching eyes
  • decreased weight
  • diarrhea
  • discharge or excessive tearing
  • dry skin
  • itching skin or rash
  • loosening of the fingernails
  • pimples
  • rash with flat lesions or small raised lesions on the skin
  • redness or soreness around the fingernails
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • swelling or inflammation of the mouth

For Healthcare Professionals

Applies to necitumumab: intravenous solution


Common (1% to 10%): Venous thromboembolic events (VTE)
Frequency not reported: Cardiopulmonary arrest[Ref]


Very common (10% or more): Rash (44%), dermatitis acneiform (15%)
Common (1% to 10%): Acne, pruritus, dry skin, skin fissures[Ref]


Very common (10% or more): Vomiting (29%), diarrhea (16%), stomatitis (11%)[Ref]


Frequency not reported: Infusion related reactions[Ref]


Very common (10% or more): Hypomagnesemia (83%), hypocalcemia (45%), hypocalcemia (albumin corrected) (36%), hypophosphatemia (31%), hypokalemia (28%), weight loss (13%)[Ref]

Nervous system

Very common (10% or more): Headache (11%)[Ref]


Common (1% to 10%): Conjunctivitis (includes conjunctivitis, eye irritation, vision blurred, conjunctivitis bacterial, dry eye, visual acuity reduced, blepharitis, allergic blepharitis, conjunctiva hemorrhage, eye infection, eye pain, lacrimation increased, ocular hyperemia, Sjogren's syndrome, visual impairment, and eye pruritus)[Ref]


Frequency not reported: Non-Squamous NSCLC -increased toxicity and increased mortality[Ref]


Common (1% to 10%): Hemoptysis, pulmonary embolism[Ref]


1. "Product Information. Portrazza (necitumumab)." Eli Lilly and Company, Indianapolis, IN.

It is possible that some side effects of necitumumab may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.