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Naloxone / oxycodone Side Effects

For the Consumer

Applies to naloxone / oxycodone: oral tablet extended release

As well as its needed effects, naloxone / oxycodone may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking naloxone / oxycodone, check with your doctor immediately:

Incidence not known:
  • Blurred vision
  • confusion
  • difficult or troubled breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • irregular, fast or slow, or shallow breathing
  • pale or blue lips, fingernails, or skin
  • seizures
  • sweating
  • unusual tiredness or weakness

If any of the following symptoms of overdose occur while taking naloxone / oxycodone, get emergency help immediately:

Symptoms of overdose:
  • Bigger, dilated, or enlarged pupils (black part of the eye)
  • change in consciousness
  • chest pain or discomfort
  • cold, clammy skin
  • coughing that sometimes produces a pink frothy sputum
  • decreased awareness or responsiveness
  • difficult, fast, noisy breathing
  • increased sensitivity of the eyes to light
  • increased sweating
  • loss of consciousness
  • severe sleepiness
  • sleepiness or unusual drowsiness
  • slow or irregular heartbeat
  • swelling in the legs and ankles

Minor Side Effects

Some naloxone / oxycodone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Nausea
Less common:
  • Abdominal or stomach pain
  • back pain
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dizziness
  • fear or nervousness
  • feeling of warmth
  • headache
  • itching skin or rash
  • muscle pain or stiffness
  • pain in the joints
  • redness of the face, neck, arms, and occasionally, upper chest
  • sudden sweating
  • trouble sleeping
  • vomiting

For Healthcare Professionals

Applies to naloxone / oxycodone: oral tablet extended release


Common (1% to 10%): Hypertension, hypotension
Uncommon (0.1% to 1%): Angina pectoris, (especially in patients with history of coronary artery disease), palpitations, peripheral edema, chest pain
Rare (less than 0.1%): Syncope
Frequency not reported: Flushing, bradycardia, ST depression, supraventricular tachycardia[Ref]


Common (1% to 10%): Pruritus, rash, cold sweat
Postmarketing reports: Hyperhidrosis, exfoliative dermatitis, dry skin, urticaria[Ref]


Common (1% to 10%): Hot flush[Ref]


Common (1% to 10%): Diarrhea, abdominal pain, dry mouth, flatulence, vomiting, nausea, anorexia, increased appetite, gastroenteritis, dyspepsia, constipation
Frequency not reported: Thirst, eructation, colic, dysphagia, stomatitis, taste perversion, dental caries, ileus, flatulence[Ref]


Frequency not reported: Urinary tract infection, micturition urgency, ureteric spasm, erectile dysfunction, urinary retention, amenorrhea[Ref]


Frequency not reported: Biliary colic, increased liver enzymes, biliary spasm, cholestasis[Ref]


Rare (less than 0.1%): Allergic reactions, anaphylactic reactions[Ref]


Common (1% to 10%): Influenza
Rare (less than 0.1%): Herpes simplex
Frequency not reported: Lymphadenopathy[Ref]


Common (1% to 10%): Loss of appetite
Rare (less than 0.1%): Dehydration, increased appetite
Frequency not reported: Increased serum triglycerides, hyponatremia[Ref]


Common (1% to 10%): Back pain, fall, arthralgia, myalgia
Frequency not reported: Myalgia, neck pain, striated and nonstriated muscle spasms, muscle twitching, muscle rigidity, osteoarthritis, abnormal gait, hypertonia, involuntary muscle contractions, abnormal coordination[Ref]

Nervous system

Common (1% to 10%): Headache, fatigue, dizziness, drug withdrawal syndrome, sedation, tremor, sinus headache, somnolence
Uncommon (0.1% to 1%): Disturbance in attention, paraesthesia, speech disorder, malaise
Rare (less than 0.1%): Convulsions (particularly in persons with epileptic disorder or predisposition to convulsions)
Frequency not reported: Syncope
Postmarketing reports: Raised intracranial pressure, sciatica, tremor, vertigo, drowsiness, paraesthesia, somnolence, speech disorder, amnesia, hypertonia, migraine, feeling hot and cold, chills, tinnitus[Ref]


Common (1% to 10%): Lacrimation increased
Uncommon (0.1% to 1%): Visual disturbances, miosis[Ref]


Common (1% to 10%): Malignant neoplasm progression


Common (1% to 10%): Drug abuse, anxiety, restlessness
Uncommon (0.1% to 1%): Abnormal thinking, confusion, depression, hallucination, altered mood, personality change, euphoric mood, decreased activity, psychomotor hyperactivity, agitation, nervousness, insomnia, perception disturbances (e.g., hallucination, derealization), reduced libido, mood changes, disorientation, dysphoria, nightmares[Ref]


Common (1% to 10%): Dyspnea, rhinorrhea, yawning
Uncommon (0.1% to 1%): Respiratory depression, bronchial spasm, spasms of nonstriated muscles, suppression of the cough reflex
Frequency not reported: Bronchitis, nasopharyngitis, pharyngitis, voice alteration, sinusitis, lower respiratory tract infection, hiccup[Ref]


1. "Product Information. Targiniq ER (naloxone-oxyCODONE)." Purdue Pharma LP, Stamford, CT.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

It is possible that some side effects of naloxone / oxycodone may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.