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Naloxone / oxycodone Side Effects

Medically reviewed by Last updated on Oct 2, 2022.

Applies to naloxone/oxycodone: oral tablet extended release.


Common (1% to 10%): Hypertension, hypotension

Uncommon (0.1% to 1%): Angina pectoris, (especially in patients with history of coronary artery disease), palpitations, peripheral edema, chest pain

Rare (less than 0.1%): Syncope

Frequency not reported: Flushing, bradycardia, ST depression, supraventricular tachycardia[Ref]


Common (1% to 10%): Pruritus, rash, cold sweat

Postmarketing reports: Hyperhidrosis, exfoliative dermatitis, dry skin, urticaria[Ref]


Common (1% to 10%): Hot flush[Ref]


Common (1% to 10%): Diarrhea, abdominal pain, dry mouth, flatulence, vomiting, nausea, anorexia, increased appetite, gastroenteritis, dyspepsia, constipation

Frequency not reported: Thirst, eructation, colic, dysphagia, stomatitis, taste perversion, dental caries, ileus, flatulence[Ref]


Frequency not reported: Urinary tract infection, micturition urgency, ureteric spasm, erectile dysfunction, urinary retention, amenorrhea[Ref]


Frequency not reported: Biliary colic, increased liver enzymes, biliary spasm, cholestasis[Ref]


Rare (less than 0.1%): Allergic reactions, anaphylactic reactions[Ref]


Common (1% to 10%): Influenza

Rare (less than 0.1%): Herpes simplex

Frequency not reported: Lymphadenopathy[Ref]


Common (1% to 10%): Loss of appetite

Rare (less than 0.1%): Dehydration, increased appetite

Frequency not reported: Increased serum triglycerides, hyponatremia[Ref]


Common (1% to 10%): Back pain, fall, arthralgia, myalgia

Frequency not reported: Myalgia, neck pain, striated and nonstriated muscle spasms, muscle twitching, muscle rigidity, osteoarthritis, abnormal gait, hypertonia, involuntary muscle contractions, abnormal coordination[Ref]

Nervous system

Common (1% to 10%): Headache, fatigue, dizziness, drug withdrawal syndrome, sedation, tremor, sinus headache, somnolence

Uncommon (0.1% to 1%): Disturbance in attention, paraesthesia, speech disorder, malaise

Rare (less than 0.1%): Convulsions (particularly in persons with epileptic disorder or predisposition to convulsions)

Frequency not reported: Syncope

Postmarketing reports: Raised intracranial pressure, sciatica, tremor, vertigo, drowsiness, paraesthesia, somnolence, speech disorder, amnesia, hypertonia, migraine, feeling hot and cold, chills, tinnitus[Ref]


Common (1% to 10%): Lacrimation increased

Uncommon (0.1% to 1%): Visual disturbances, miosis[Ref]


Common (1% to 10%): Malignant neoplasm progression


Common (1% to 10%): Drug abuse, anxiety, restlessness

Uncommon (0.1% to 1%): Abnormal thinking, confusion, depression, hallucination, altered mood, personality change, euphoric mood, decreased activity, psychomotor hyperactivity, agitation, nervousness, insomnia, perception disturbances (e.g., hallucination, derealization), reduced libido, mood changes, disorientation, dysphoria, nightmares[Ref]


Common (1% to 10%): Dyspnea, rhinorrhea, yawning

Uncommon (0.1% to 1%): Respiratory depression, bronchial spasm, spasms of nonstriated muscles, suppression of the cough reflex

Frequency not reported: Bronchitis, nasopharyngitis, pharyngitis, voice alteration, sinusitis, lower respiratory tract infection, hiccup[Ref]

More about naloxone / oxycodone

Patient resources

Other brands

Targiniq ER

Related treatment guides


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Targiniq ER (naloxone-oxycodone)." Purdue Pharma LP (2014):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.