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Naloxone / oxycodone Side Effects

For the Consumer

Applies to naloxone / oxycodone: oral tablet extended release

Along with its needed effects, naloxone/oxycodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking naloxone / oxycodone:

Incidence Not Known

  • Blurred vision
  • confusion
  • difficult or troubled breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • irregular, fast or slow, or shallow breathing
  • pale or blue lips, fingernails, or skin
  • seizures
  • sweating
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking naloxone / oxycodone:

Symptoms of Overdose

  • Bigger, dilated, or enlarged pupils (black part of the eye)
  • change in consciousness
  • chest pain or discomfort
  • cold, clammy skin
  • coughing that sometimes produces a pink frothy sputum
  • decreased awareness or responsiveness
  • difficult, fast, noisy breathing
  • increased sensitivity of the eyes to light
  • increased sweating
  • loss of consciousness
  • severe sleepiness
  • sleepiness or unusual drowsiness
  • slow or irregular heartbeat
  • swelling in the legs and ankles

Some side effects of naloxone / oxycodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

  • Abdominal or stomach pain
  • back pain
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dizziness
  • fear or nervousness
  • feeling of warmth
  • headache
  • itching skin or rash
  • muscle pain or stiffness
  • pain in the joints
  • redness of the face, neck, arms, and occasionally, upper chest
  • sudden sweating
  • trouble sleeping
  • vomiting

For Healthcare Professionals

Applies to naloxone / oxycodone: oral tablet extended release


Common (1% to 10%): Hypertension, hypotension

Uncommon (0.1% to 1%): Angina pectoris, (especially in patients with history of coronary artery disease), palpitations, peripheral edema, chest pain

Rare (less than 0.1%): Syncope

Frequency not reported: Flushing, bradycardia, ST depression, supraventricular tachycardia[Ref]


Common (1% to 10%): Pruritus, rash, cold sweat

Postmarketing reports: Hyperhidrosis, exfoliative dermatitis, dry skin, urticaria[Ref]


Common (1% to 10%): Hot flush[Ref]


Common (1% to 10%): Diarrhea, abdominal pain, dry mouth, flatulence, vomiting, nausea, anorexia, increased appetite, gastroenteritis, dyspepsia, constipation

Frequency not reported: Thirst, eructation, colic, dysphagia, stomatitis, taste perversion, dental caries, ileus, flatulence[Ref]


Frequency not reported: Urinary tract infection, micturition urgency, ureteric spasm, erectile dysfunction, urinary retention, amenorrhea[Ref]


Frequency not reported: Biliary colic, increased liver enzymes, biliary spasm, cholestasis[Ref]


Rare (less than 0.1%): Allergic reactions, anaphylactic reactions[Ref]


Common (1% to 10%): Influenza

Rare (less than 0.1%): Herpes simplex

Frequency not reported: Lymphadenopathy[Ref]


Common (1% to 10%): Loss of appetite

Rare (less than 0.1%): Dehydration, increased appetite

Frequency not reported: Increased serum triglycerides, hyponatremia[Ref]


Common (1% to 10%): Back pain, fall, arthralgia, myalgia

Frequency not reported: Myalgia, neck pain, striated and nonstriated muscle spasms, muscle twitching, muscle rigidity, osteoarthritis, abnormal gait, hypertonia, involuntary muscle contractions, abnormal coordination[Ref]

Nervous system

Common (1% to 10%): Headache, fatigue, dizziness, drug withdrawal syndrome, sedation, tremor, sinus headache, somnolence

Uncommon (0.1% to 1%): Disturbance in attention, paraesthesia, speech disorder, malaise

Rare (less than 0.1%): Convulsions (particularly in persons with epileptic disorder or predisposition to convulsions)

Frequency not reported: Syncope

Postmarketing reports: Raised intracranial pressure, sciatica, tremor, vertigo, drowsiness, paraesthesia, somnolence, speech disorder, amnesia, hypertonia, migraine, feeling hot and cold, chills, tinnitus[Ref]


Common (1% to 10%): Lacrimation increased

Uncommon (0.1% to 1%): Visual disturbances, miosis[Ref]


Common (1% to 10%): Malignant neoplasm progression


Common (1% to 10%): Drug abuse, anxiety, restlessness

Uncommon (0.1% to 1%): Abnormal thinking, confusion, depression, hallucination, altered mood, personality change, euphoric mood, decreased activity, psychomotor hyperactivity, agitation, nervousness, insomnia, perception disturbances (e.g., hallucination, derealization), reduced libido, mood changes, disorientation, dysphoria, nightmares[Ref]


Common (1% to 10%): Dyspnea, rhinorrhea, yawning

Uncommon (0.1% to 1%): Respiratory depression, bronchial spasm, spasms of nonstriated muscles, suppression of the cough reflex

Frequency not reported: Bronchitis, nasopharyngitis, pharyngitis, voice alteration, sinusitis, lower respiratory tract infection, hiccup[Ref]


1. "Product Information. Targiniq ER (naloxone-oxyCODONE)." Purdue Pharma LP, Stamford, CT.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.