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Naloxone / oxycodone Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 15, 2023.

Applies to naloxone / oxycodone: oral tablet extended release.

Warning

You should not use this medicine if you have severe asthma or breathing problems, severe liver disease, or a blockage in your stomach or intestines.

This medicine can slow or stop your breathing, and may be habit-forming. Use only your prescribed dose, and swallow the pill whole to avoid a potentially fatal dose. Never share naloxone and oxycodone medicine with another person.

MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Oxycodone may cause life-threatening withdrawal symptoms in a newborn if the mother has taken this medicine during pregnancy.

Some medicines can interact with naloxone and oxycodone, and cause dangerous side effects or death. Tell your doctor about all your current medicines and any you start or stop using.

Do not drink alcohol. Dangerous side effects or death could occur.

Get emergency medical help if you have signs of an allergic reaction: hives; feeling light-headed; chest pain, fast heartbeats, difficult breathing; swelling of your face, lips, tongue, or throat.

Like other narcotic medicines, oxycodone can slow your breathing. Death may occur if breathing becomes too weak.

Call your doctor at once if you have:

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Naloxone and oxycodone is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to naloxone / oxycodone: oral tablet extended release.

Cardiovascular

Common (1% to 10%): Hypertension, hypotension

Uncommon (0.1% to 1%): Angina pectoris, (especially in patients with history of coronary artery disease), palpitations, peripheral edema, chest pain

Rare (less than 0.1%): Syncope

Frequency not reported: Flushing, bradycardia, ST depression, supraventricular tachycardia[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash, cold sweat

Postmarketing reports: Hyperhidrosis, exfoliative dermatitis, dry skin, urticaria[Ref]

Endocrine

Common (1% to 10%): Hot flush[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, abdominal pain, dry mouth, flatulence, vomiting, nausea, anorexia, increased appetite, gastroenteritis, dyspepsia, constipation

Frequency not reported: Thirst, eructation, colic, dysphagia, stomatitis, taste perversion, dental caries, ileus, flatulence[Ref]

Genitourinary

Frequency not reported: Urinary tract infection, micturition urgency, ureteric spasm, erectile dysfunction, urinary retention, amenorrhea[Ref]

Hepatic

Frequency not reported: Biliary colic, increased liver enzymes, biliary spasm, cholestasis[Ref]

Hypersensitivity

Rare (less than 0.1%): Allergic reactions, anaphylactic reactions[Ref]

Immunologic

Common (1% to 10%): Influenza

Rare (less than 0.1%): Herpes simplex

Frequency not reported: Lymphadenopathy[Ref]

Metabolic

Common (1% to 10%): Loss of appetite

Rare (less than 0.1%): Dehydration, increased appetite

Frequency not reported: Increased serum triglycerides, hyponatremia[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, fall, arthralgia, myalgia

Frequency not reported: Myalgia, neck pain, striated and nonstriated muscle spasms, muscle twitching, muscle rigidity, osteoarthritis, abnormal gait, hypertonia, involuntary muscle contractions, abnormal coordination[Ref]

Nervous system

Common (1% to 10%): Headache, fatigue, dizziness, drug withdrawal syndrome, sedation, tremor, sinus headache, somnolence

Uncommon (0.1% to 1%): Disturbance in attention, paraesthesia, speech disorder, malaise

Rare (less than 0.1%): Convulsions (particularly in persons with epileptic disorder or predisposition to convulsions)

Frequency not reported: Syncope

Postmarketing reports: Raised intracranial pressure, sciatica, tremor, vertigo, drowsiness, paraesthesia, somnolence, speech disorder, amnesia, hypertonia, migraine, feeling hot and cold, chills, tinnitus[Ref]

Ocular

Common (1% to 10%): Lacrimation increased

Uncommon (0.1% to 1%): Visual disturbances, miosis[Ref]

Oncologic

Common (1% to 10%): Malignant neoplasm progression

Psychiatric

Common (1% to 10%): Drug abuse, anxiety, restlessness

Uncommon (0.1% to 1%): Abnormal thinking, confusion, depression, hallucination, altered mood, personality change, euphoric mood, decreased activity, psychomotor hyperactivity, agitation, nervousness, insomnia, perception disturbances (e.g., hallucination, derealization), reduced libido, mood changes, disorientation, dysphoria, nightmares[Ref]

Respiratory

Common (1% to 10%): Dyspnea, rhinorrhea, yawning

Uncommon (0.1% to 1%): Respiratory depression, bronchial spasm, spasms of nonstriated muscles, suppression of the cough reflex

Frequency not reported: Bronchitis, nasopharyngitis, pharyngitis, voice alteration, sinusitis, lower respiratory tract infection, hiccup[Ref]

More about naloxone / oxycodone

Patient resources

Other brands

Targiniq ER

Professional resources

Other brands

Targiniq ER

Related treatment guides

References

1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Cerner Multum, Inc. Australian Product Information.

3. Product Information. Targiniq ER (naloxone-oxycodone). Purdue Pharma LP. 2014.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.