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Naloxone / oxycodone Side Effects

Applies to naloxone/oxycodone: oral tablet extended release

Cardiovascular

Common (1% to 10%): Hypertension, hypotension

Uncommon (0.1% to 1%): Angina pectoris, (especially in patients with history of coronary artery disease), palpitations, peripheral edema, chest pain

Rare (less than 0.1%): Syncope

Frequency not reported: Flushing, bradycardia, ST depression, supraventricular tachycardia[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash, cold sweat

Postmarketing reports: Hyperhidrosis, exfoliative dermatitis, dry skin, urticaria[Ref]

Endocrine

Common (1% to 10%): Hot flush[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, abdominal pain, dry mouth, flatulence, vomiting, nausea, anorexia, increased appetite, gastroenteritis, dyspepsia, constipation

Frequency not reported: Thirst, eructation, colic, dysphagia, stomatitis, taste perversion, dental caries, ileus, flatulence[Ref]

Genitourinary

Frequency not reported: Urinary tract infection, micturition urgency, ureteric spasm, erectile dysfunction, urinary retention, amenorrhea[Ref]

Hepatic

Frequency not reported: Biliary colic, increased liver enzymes, biliary spasm, cholestasis[Ref]

Hypersensitivity

Rare (less than 0.1%): Allergic reactions, anaphylactic reactions[Ref]

Immunologic

Common (1% to 10%): Influenza

Rare (less than 0.1%): Herpes simplex

Frequency not reported: Lymphadenopathy[Ref]

Metabolic

Common (1% to 10%): Loss of appetite

Rare (less than 0.1%): Dehydration, increased appetite

Frequency not reported: Increased serum triglycerides, hyponatremia[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, fall, arthralgia, myalgia

Frequency not reported: Myalgia, neck pain, striated and nonstriated muscle spasms, muscle twitching, muscle rigidity, osteoarthritis, abnormal gait, hypertonia, involuntary muscle contractions, abnormal coordination[Ref]

Nervous system

Common (1% to 10%): Headache, fatigue, dizziness, drug withdrawal syndrome, sedation, tremor, sinus headache, somnolence

Uncommon (0.1% to 1%): Disturbance in attention, paraesthesia, speech disorder, malaise

Rare (less than 0.1%): Convulsions (particularly in persons with epileptic disorder or predisposition to convulsions)

Frequency not reported: Syncope

Postmarketing reports: Raised intracranial pressure, sciatica, tremor, vertigo, drowsiness, paraesthesia, somnolence, speech disorder, amnesia, hypertonia, migraine, feeling hot and cold, chills, tinnitus[Ref]

Ocular

Common (1% to 10%): Lacrimation increased

Uncommon (0.1% to 1%): Visual disturbances, miosis[Ref]

Oncologic

Common (1% to 10%): Malignant neoplasm progression

Psychiatric

Common (1% to 10%): Drug abuse, anxiety, restlessness

Uncommon (0.1% to 1%): Abnormal thinking, confusion, depression, hallucination, altered mood, personality change, euphoric mood, decreased activity, psychomotor hyperactivity, agitation, nervousness, insomnia, perception disturbances (e.g., hallucination, derealization), reduced libido, mood changes, disorientation, dysphoria, nightmares[Ref]

Respiratory

Common (1% to 10%): Dyspnea, rhinorrhea, yawning

Uncommon (0.1% to 1%): Respiratory depression, bronchial spasm, spasms of nonstriated muscles, suppression of the cough reflex

Frequency not reported: Bronchitis, nasopharyngitis, pharyngitis, voice alteration, sinusitis, lower respiratory tract infection, hiccup[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Targiniq ER (naloxone-oxyCODONE)." Purdue Pharma LP, Stamford, CT.

More about naloxone / oxycodone

Consumer resources

Other brands
Targiniq ER

Professional resources

Related treatment guides

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.