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Miglitol Side Effects

In Summary

Commonly reported side effects of miglitol include: abdominal pain, diarrhea, gastrointestinal signs and symptoms, and flatulence. Other side effects include: decreased serum iron, and skin rash. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to miglitol: oral tablet

Some side effects of miglitol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bloated full feeling
  • excess air or gas in stomach or intestines
  • increase in bowel movements
  • loose stools
  • passing gas
  • soft stools
  • stomach or abdomen pain
Less common
  • Skin rash

For Healthcare Professionals

Applies to miglitol: oral tablet

General

The most commonly reported adverse reactions include gastrointestinal symptoms; they tend to diminish in frequency and intensity with time.

Gastrointestinal

Very common (10% or more): Flatulence (41.5%), diarrhea (28.7%), abdominal pain (11.7%)
Postmarketing reports: Pneumatosis cystoides intestinalis (may present with symptoms of diarrhea, mucus discharge, rectal bleeding, and constipation), ileus (including paralytic ileus), subileus, gastrointestinal pain, nausea, abdominal distention.[Ref]

The severity of gastrointestinal symptoms may be decreased by dosage reduction and avoiding high gas-producing foods and sucrose. Some studies have demonstrated a decrease in the severity of gastrointestinal effects over time with continued administration.[Ref]

Dermatologic

Common (1% to 10%): Skin rash[Ref]

Hematologic

Common (1% to 10%): Low serum iron[Ref]

References

1. "Product Information. Glyset (miglitol)." Bayer, West Haven, CT.

Some side effects of miglitol may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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