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Meperidine Side Effects

For the Consumer

Applies to meperidine: oral solution, oral syrup, oral tablet

Other dosage forms:

Along with its needed effects, meperidine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking meperidine:

Incidence Not Known

  • Blurred vision
  • chest pain or discomfort
  • cold, clammy skin
  • confusion
  • cough
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult or troubled breathing
  • difficulty in passing urine (dribbling)
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, slow, pounding, or irregular heartbeat
  • feeling of warmth
  • hives, itching, or skin rash
  • irregular, fast, slow, or shallow breathing
  • lightheadedness, dizziness, or fainting
  • muscle twitching or jerking
  • painful urination
  • pale or blue lips, fingernails, or skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the face, neck, arms, and occasionally, upper chest
  • rhythmic movement of the muscles
  • seizures
  • shakiness in the legs, arms, hands, or feet
  • sweating
  • tightness in the chest
  • trembling or shaking of the hands or feet
  • unusual tiredness or weakness
  • upper abdominal or stomach pain

Get emergency help immediately if any of the following symptoms of overdose occur while taking meperidine:

Symptoms of Overdose

  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • change in consciousness
  • decreased awareness or responsiveness
  • loss of consciousness
  • severe sleepiness
  • sleepiness or unusual drowsiness

Some side effects of meperidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Incidence Not Known

  • Anxiety
  • blurred or loss of vision
  • confusion about identity, place, and time
  • deep or fast breathing with dizziness
  • difficulty having a bowel movement
  • disturbed color perception
  • double vision
  • dry mouth
  • false or unusual sense of well-being
  • halos around lights
  • headache
  • hives or welts
  • irritability
  • nervousness
  • night blindness
  • numbness of the feet, hands, and around the mouth
  • overbright appearance of lights
  • redness of the skin
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • trouble with sleeping
  • tunnel vision
  • weakness

For Healthcare Professionals

Applies to meperidine: compounding powder, injectable solution, intravenous solution, oral syrup, oral tablet

General

The most frequently reported adverse reactions have included lightheadedness, dizziness, sedation, nausea, vomiting, and sweating.[Ref]

Respiratory

Frequency not reported: Respiratory depression, respiratory arrest[Ref]

Nervous system

Frequency not reported: Serotonin syndrome, hyperexcitability, convulsions, weakness, headache, tremor, involuntary muscle movements (e.g. muscle twitches, myoclonus), delirium, dizziness, drowsiness, fainting, neurotoxicity, lightheadedness[Ref]

Therapeutic doses of this drug have precipitated unpredictable, severe, and occasionally fatal reactions in patients who have received MAOIs within 14 days of receiving this drug. The mechanism of this reaction is unclear, but may be related to preexisting hyperphenylalaninemia. Reactions have included coma, severe respiratory depression, cyanosis, and hypotension. IV hydrocortisone or prednisolone have been used to treat severe reactions, with IV chlorpromazine used in cases exhibiting hypertension and hyperpyrexia. The usefulness and safety of narcotic antagonists is unknown.

Neurotoxicity associated with increased concentrations of active metabolite have occurred. Reactions have included a range of excitatory effects including tremor, hallucinations, seizures, coma, and mood changes.[Ref]

Psychiatric

Frequency not reported: Mood changes (e.g. euphoria, dysphoria), agitation, transient hallucinations and disorientation, confusion, dependence, anxiety, nervousness[Ref]

Cardiovascular

Frequency not reported: Severe hypotension, orthostatic hypotension, syncope, shock, cardiac arrest, circulatory depression, flushing, tachycardia, bradycardia, palpitations, hypotension, hypertension[Ref]

Hypersensitivity

Frequency not reported: Wheel and flare over the vein with IV injection, hypersensitivity reactions, anaphylaxis, histamine release leading to hypotension and/or tachycardia, sweating, flushing, and pruritus[Ref]

Local

Frequency not reported: Sensory-motor paralysis, phlebitis, injection site pain, local tissue irritation and induration following subcutaneous injection[Ref]

Inadvertent injection about a nerve trunk may result in sensory-motor paralysis which is usually transitory. Phlebitis has been reported following IV injection.[Ref]

Other

Frequency not reported: Vertigo, hypothermia[Ref]

Genitourinary

Frequency not reported: Urinary retention, micturition difficulties, decreased libido, renal colic, anuria[Ref]

Gastrointestinal

Frequency not reported: Dry mouth, constipation, biliary tract spasm, nausea, vomiting, decreased gastric emptying[Ref]

Dermatologic

Frequency not reported: Pruritus, urticaria, other skin rashes, sweating[Ref]

Musculoskeletal

Frequency not reported: Muscle twitching, muscle rigidity[Ref]

Endocrine

Frequency not reported: Adrenal insufficiency, androgen deficiency[Ref]

Hepatic

Frequency not reported: Biliary spasm, choledochoduodenal sphincter spasm[Ref]

Renal

Frequency not reported: Antidiuretic effect[Ref]

Ocular

Frequency not reported: Visual disturbances, dry eye, pupillary constriction, miosis, decreased corneal reflex, mydriasis[Ref]

Metabolic

Frequency not reported: Anorexia[Ref]

References

1. "Product Information. Demerol HCl (meperidine)." Validus Pharmaceuticals Inc, Parsippany, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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