Skip to main content

Mapap Cold Formula Side Effects

Generic name: acetaminophen / dextromethorphan / phenylephrine

Medically reviewed by Last updated on Apr 16, 2024.

Note: This document contains side effect information about acetaminophen / dextromethorphan / phenylephrine. Some dosage forms listed on this page may not apply to the brand name Mapap Cold Formula.

Applies to acetaminophen / dextromethorphan / phenylephrine: oral capsule, oral tablet.

Serious side effects of Mapap Cold Formula

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Other side effects of Mapap Cold Formula

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to acetaminophen/dextromethorphan/phenylephrine: oral capsule, oral liquid, oral powder for reconstitution, oral suspension, oral syrup, oral tablet.


Very rare (less than 0.01%): Hepatic dysfunction (acetaminophen)[Ref]

Nervous system

Uncommon (0.1% to 1%): Drowsiness, dizziness, fatigue, dystonias (dextromethorphan)

Frequency not reported: Headache, dizziness, insomnia (phenylephrine)

Postmarketing reports: Serotonin syndrome (dextromethorphan)[Ref]

Serotonin syndrome has been reported with concomitant use of dextromethorphan and either a monoamine oxidase inhibitor (MAOI) or a serotonergic drug such as a selective serotonin reuptake inhibitor (SSRI). Serotonin syndrome causes changes in mental status, restlessness, myoclonus, hyperreflexia, diaphoresis, shivering, tremor, and hypertension.[Ref]


Rare (less than 0.1%): Allergic reactions (e.g. rash, urticaria, allergic dermatitis) (phenylephrine)

Very rare (less than 0.01%): Anaphylaxis, cutaneous hypersensitivity reactions (including skin rashes, angioedema, and Stevens Johnson syndrome) (acetaminophen)

Postmarketing reports: Allergic reactions (e.g. rash, urticaria, angioedema) (dextromethorphan)[Ref]


Rare (less than 0.1%): Tachycardia, palpitations (phenylephrine)

Frequency not reported: Increased blood pressure, arrhythmias (phenylephrine)[Ref]


Uncommon (0.1% to 1%): Gastrointestinal disturbance, nausea, vomiting, abdominal discomfort, constipation (dextromethorphan)

Frequency not reported: Nausea, vomiting (phenylephrine)[Ref]


Frequency not reported: Nervousness, anxiety (phenylephrine)[Ref]


Very rare (less than 0.01%): Bronchospasm (especially in patients sensitive to aspirin/other NSAIDs) (acetaminophen)[Ref]


Rare (less than 0.1%): Dysuria, urinary retention (phenylephrine)[Ref]

Dysuria and urinary retention are most likely to occur with preexisting bladder outlet obstruction (e.g. prostatic hypertrophy)[Ref]


Very rare (less than 0.01%): Thrombocytopenia (acetaminophen)[Ref]


Rare (less than 0.1%): Mydriasis, acute closure glaucoma (phenylephrine)[Ref]

Phenylephrine is most likely to cause mydriasis and acute closure glaucoma in patients with pre-existing closed angle glaucoma.[Ref]


1. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.