Acetaminophen / Dextromethorphan / Phenylephrine Dosage
Medically reviewed by Drugs.com. Last updated on Aug 7, 2023.
Applies to the following strengths: 325 mg-10 mg-5 mg; 325 mg-10 mg-5 mg/15 mL; 650 mg-20 mg-10 mg; 500 mg-20 mg-10 mg; 650 mg-20 mg-10 mg/30 mL; 160 mg-5 mg-2.5 mg/5 mL
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Cold Symptoms
Acetaminophen 325 mg/ dextromethorphan 10 mg/ phenylephrine 5 mg per softgel/caplet: 2 softgels/caplets every 4 hours
Maximum dose: 4 doses (8 softgels/caplets) per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ phenylephrine 5 mg per 15 mL liquid: 30 mL every 4 hours
Maximum dose: 5 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ phenylephrine 10 mg per packet: One packet in water every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 6 hours
Maximum dose: 5 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 30 mg/ phenylephrine 12.5 mg per 30 mL liquid:
12 years and older: 30 mL every 6 hours
6 to under 12 years: 15 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Usual Pediatric Dose for Cold Symptoms
Acetaminophen 325 mg/ dextromethorphan 10 mg/ phenylephrine 5 mg per softgel/caplet:
12 years and older: 2 softgels/caplets every 4 hours
Maximum dose: 4 doses (8 softgels/caplets) per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ phenylephrine 5 mg per 15 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 5 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ phenylephrine 10 mg per packet:
12 years and older: One packet in water every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 6 hours
Maximum dose: 5 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 30 mg/ phenylephrine 12.5 mg per 30 mL liquid:
12 years and older: 30 mL every 6 hours
6 to under 12 years: 15 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Use with caution.
Precautions
CONTRAINDICATIONS:
- Current use of any other drug containing acetaminophen.
- Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.
- Current use of any other drug containing diphenhydramine, including topical preparations.
Safety and efficacy have not been established in patients younger than 6 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- Swallow caplets and softgels whole; do not crush or chew.
- Use only provided measuring cups.
Patient advice:
- Take only as directed.
- This product contains acetaminophen; severe liver damage may occur with use of over 4000 mg in 24 hours, use with other acetaminophen-containing medications, or having 3 or more alcoholic drinks a day during use.
- Do not use with any other drug containing acetaminophen.
- Avoid drinking alcohol while on this drug.
- If cough comes back, or is accompanied or followed by fever, headache that lasts, or rash, seek medical care promptly.
- Discontinue for cough, pain, or nasal congestion that worsens or lasts over 7 days, if new symptoms arise, fever worsens or lasts over 3 days, or for redness or swelling.
More about acetaminophen / dextromethorphan / phenylephrine
- Check interactions
- Compare alternatives
- Reviews (3)
- Drug images
- Side effects
- During pregnancy
- Drug class: upper respiratory combinations
Patient resources
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.