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Acetaminophen / Dextromethorphan / Phenylephrine Dosage

Medically reviewed by Drugs.com. Last updated on Oct 20, 2020.

Applies to the following strengths: 325 mg-10 mg-5 mg; 325 mg-10 mg-5 mg/15 mL; 650 mg-20 mg-10 mg; 500 mg-20 mg-10 mg; 650 mg-20 mg-10 mg/30 mL; 160 mg-5 mg-2.5 mg/5 mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cold Symptoms

Acetaminophen 325 mg/ dextromethorphan 10 mg/ phenylephrine 5 mg per softgel/caplet: 2 softgels/caplets every 4 hours
Maximum dose: 4 doses (8 softgels/caplets) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ phenylephrine 5 mg per 15 mL liquid: 30 mL every 4 hours
Maximum dose: 5 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ phenylephrine 10 mg per packet: One packet in water every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 6 hours
Maximum dose: 5 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 30 mg/ phenylephrine 12.5 mg per 30 mL liquid:
12 years and older: 30 mL every 6 hours
6 to under 12 years: 15 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Usual Pediatric Dose for Cold Symptoms

Acetaminophen 325 mg/ dextromethorphan 10 mg/ phenylephrine 5 mg per softgel/caplet:
12 years and older: 2 softgels/caplets every 4 hours
Maximum dose: 4 doses (8 softgels/caplets) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ phenylephrine 5 mg per 15 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 5 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ phenylephrine 10 mg per packet:
12 years and older: One packet in water every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 6 hours
Maximum dose: 5 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 30 mg/ phenylephrine 12.5 mg per 30 mL liquid:
12 years and older: 30 mL every 6 hours
6 to under 12 years: 15 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use with caution.

Precautions

CONTRAINDICATIONS:
-Current use of any other drug containing acetaminophen.
-Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.
-Current use of any other drug containing diphenhydramine, including topical preparations.

Safety and efficacy have not been established in patients younger than 6 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Swallow caplets and softgels whole; do not crush or chew.
-Use only provided measuring cups.

Patient advice:
-Take only as directed.
-This product contains acetaminophen; severe liver damage may occur with use of over 4000 mg in 24 hours, use with other acetaminophen-containing medications, or having 3 or more alcoholic drinks a day during use.
-Do not use with any other drug containing acetaminophen.
-Avoid drinking alcohol while on this drug.
-If cough comes back, or is accompanied or followed by fever, headache that lasts, or rash, seek medical care promptly.
-Discontinue for cough, pain, or nasal congestion that worsens or lasts over 7 days, if new symptoms arise, fever worsens or lasts over 3 days, or for redness or swelling.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.