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Lucentis Side Effects

Generic Name: ranibizumab ophthalmic

Note: This page contains information about the side effects of ranibizumab ophthalmic. Some of the dosage forms included on this document may not apply to the brand name Lucentis.

In Summary

Common side effects of Lucentis include: cataract, increased intraocular pressure, and intraocular inflammation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ranibizumab ophthalmic: intraocular solution

In addition to its needed effects, some unwanted effects may be caused by ranibizumab ophthalmic (the active ingredient contained in Lucentis). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking ranibizumab ophthalmic, check with your doctor or nurse immediately:

More common:
  • Blindness
  • bloody eye
  • blurred vision or loss of vision
  • decreased vision or other changes in vision
  • disturbed color perception
  • dizziness
  • double vision
  • dry eye
  • eye pain
  • fainting
  • feeling of having something in the eye
  • halos around lights
  • headache
  • night blindness
  • overbright appearance of lights
  • pain or tenderness around the eyes and cheekbones
  • red, sore eyes
  • redness of the white part of the eyes or inside of the eyelids
  • redness, swelling, or itching of the eyelid
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
  • sensitivity of the eye to light
  • tearing of the eyes
  • tunnel vision
  • watering of the eyes
Less common:
  • Body aches or pain
  • chest pain
  • chills
  • cough
  • difficulty with breathing
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • general feeling of discomfort or illness
  • head congestion
  • hoarseness, loss of voice, or other voice changes
  • loss of consciousness
  • muscle aches and pains
  • nasal congestion
  • pain in the chest, groin, or legs, especially the calves
  • painful blisters on the trunk of the body
  • pale skin
  • runny nose
  • severe, sudden headache
  • shivering
  • slurred speech
  • sneezing
  • sore throat
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath
  • sweating
  • tightness in the chest
  • trouble sleeping
  • unexplained weight loss
  • unusual tiredness or weakness

Minor Side Effects

Some of the side effects that can occur with ranibizumab ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Back pain
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • muscle stiffness
  • swelling or redness in the joints

For Healthcare Professionals

Applies to ranibizumab ophthalmic: intraocular solution


-Very common (10% or more): Conjunctival hemorrhage (up to 74%), eye pain (up to 35%), vitreous floaters (up to 27%), increased intraocular pressure (up to 24%), vitreous detachment (up to 21%), intraocular inflammation (up to 18%), vision disturbance/blurred vision (up to 18%), cataract (up to 17%), foreign body sensation in eyes (up to 16%), eye irritation (up to 15%), increased lacrimation (up to 14%), blepharitis (up to 12%), dry eye (up to 12%), eye pruritus (up to 12%), ocular hyperemia (up to 11%), maculopathy (up to 11%), retinal disorder (10%), vitreitis, retinal hemorrhage
-Common (1% to 10%): Retinal degeneration, retinal detachment, retinal tear, retinal pigment epithelium detachment, retinal pigment epithelium tear, reduced visual acuity, vitreous hemorrhage, vitreous disorder, uveitis, iritis, iridocyclitis, subcapsular cataract, punctuate keratitis, corneal abrasion, anterior chamber flare, eye hemorrhage, conjunctivitis, allergic conjunctivitis, eye discharge, photopsia, photophobia, ocular discomfort, eyelid edema, eyelid pain, conjunctival hyperemia, posterior capsule opacification, endophthalmitis, injection site hemorrhage
-Uncommon (0.1% to 1%): Blindness, endophthalmitis, hypopyon, hyphema, keratopathy, iris adhesion, corneal deposits, corneal edema, corneal striae, injection site pain, injection site irritation, abnormal sensation in eye, eyelid irritation[Ref]


Very common (10% or more): Nasopharyngitis (up to 16%), bronchitis (up to 11%)
Common (1% to 10%): Cough, upper respiratory tract infection, sinusitis, chronic obstructive pulmonary disease[Ref]

Nervous system

Very common (10% or more): Headache (up to 12%)
Common (1% to 10%): Peripheral neuropathy, stroke[Ref]


Very common (10% or more): Anemia (up to 11%)[Ref]


Very common (10% or more): Arthralgia (up to 11%)[Ref]


Very common (10% or more): Arterial thromboembolic events (up to 10.8%)
Common (1% to 10%): Peripheral edema, atrial fibrillation[Ref]


Very common (10% or more): Nausea (up to 10%)
Common (1% to 10%): Constipation, gastroesophageal reflux disease[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Hypersensitivity reactions[Ref]


Common (1% to 10%): Immunoreactivity, seasonal allergy, allergic reactions (rash, urticaria, pruritus, erythema)[Ref]


Common (1% to 10%): Hypercholesterolemia[Ref]


Common (1% to 10%): Influenza, would healing complications, fatal events
Frequency not reported: Non-ocular hemorrhage[Ref]


Common (1% to 10%): Anxiety[Ref]


Common (1% to 10%): Renal failure, chronic renal failure[Ref]


1. "Product Information. Lucentis (ranibizumab ophthalmic)." Genentech, South San Francisco, CA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Lucentis may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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