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Lotrisone Side Effects

Generic Name: betamethasone / clotrimazole topical

Note: This document contains side effect information about betamethasone / clotrimazole topical. Some of the dosage forms listed on this page may not apply to the brand name Lotrisone.

In Summary

Common side effects of Lotrisone include: adrenal suppression. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to betamethasone/clotrimazole topical: topical cream, topical lotion

Along with its needed effects, betamethasone/clotrimazole topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking betamethasone/clotrimazole topical:

Less common
  • Blistering, burning, itching, peeling, dryness, redness, or other signs of skin irritation not present before use of this medicine
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • hives
  • Cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • rash
  • stinging
  • swelling
Incidence not known
  • Abdominal or stomach pain
  • dry mouth
  • full or round face, neck, or trunk
  • irritability
  • nausea
  • reddish purple lines on the arms, face, legs, trunk, or groin
  • redness and scaling around the mouth
  • softening of the skin
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to betamethasone / clotrimazole topical: topical cream, topical lotion


The most frequently reported side effects are rash, edema, paresthesia, and secondary infections.[Ref]


Topical corticosteroids:
-Frequency not reported: Burning, itching, irritation, dryness, folliculitis, blistering, peeling, redness, swelling, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria, irritation, telangiectasia, sensitization[Ref]


Frequency not reported: Hypothalamic-pituitary adrenal (HPA) axis suppression, Cushing's syndrome[Ref]

Nervous system

Common (1% to 10%): Paresthesia
Frequency not reported: Intracranial hypertension[Ref]


Frequency not reported: Growth retardation[Ref]


Frequency not reported: Rash, maculopapular rash

Betamethasone dipropionate:
-Frequency not reported: Burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hyperpigmentation, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, skin atrophy, striae miliaria, ecchymoses, telangiectasia

-Frequency not reported: Erythema, stinging, blistering, peeling, pruritus, urticaria, general irritation[Ref]


Betamethasone dipropionate:
-Frequency not reported: Sensitization[Ref]


Topical corticosteroids:
-Frequency not reported: Glucosuria[Ref]


Betamethasone dipropionate:
-Frequency not reported: Blurred vision[Ref]


Topical corticosteroids:
-Frequency not reported: Hyperglycemia[Ref]


Frequency not reported: Edema, secondary infection

Betamethasone dipropionate:
-Frequency not reported: Secondary infection

-Frequency not reported: Edema[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Lotrisone (betamethasone-clotrimazole)." Schering Laboratories, Kenilworth, NJ.

Some side effects of Lotrisone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.