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Lotrisone Side Effects

Generic name: betamethasone / clotrimazole topical

Medically reviewed by Last updated on Aug 29, 2022.

Note: This document contains side effect information about betamethasone / clotrimazole topical. Some dosage forms listed on this page may not apply to the brand name Lotrisone.


Common side effects of Lotrisone include: adrenal suppression. Continue reading for a comprehensive list of adverse effects.

Applies to betamethasone/clotrimazole topical: topical cream, topical lotion.

Serious side effects of Lotrisone

Along with its needed effects, betamethasone/clotrimazole topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking betamethasone/clotrimazole topical:

Less common

  • Blistering, burning, itching, peeling, dryness, redness, or other signs of skin irritation not present before use of this medicine
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • hives


  • Chills
  • cough
  • fever
  • hoarseness
  • lower back or side pain
  • painful or difficult urination
  • rash
  • stinging
  • swelling

Incidence not known

  • Blindness
  • blurred vision
  • change in vision
  • decreased vision
  • dry mouth
  • eye pain
  • full or round face, neck, or trunk
  • headache
  • irritability
  • nausea
  • reddish purple lines on the arms, face, legs, trunk, or groin
  • redness and scaling around the mouth
  • softening of the skin
  • stomach pain
  • tearing
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to betamethasone / clotrimazole topical: topical cream, topical lotion.


The most frequently reported side effects are rash, edema, paresthesia, and secondary infections.[Ref]


Topical corticosteroids:

-Frequency not reported: Burning, itching, irritation, dryness, folliculitis, blistering, peeling, redness, swelling, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria, irritation, telangiectasia, sensitization[Ref]


Frequency not reported: Hypothalamic-pituitary adrenal (HPA) axis suppression, Cushing's syndrome[Ref]

Nervous system

Common (1% to 10%): Paresthesia

Frequency not reported: Intracranial hypertension[Ref]


Frequency not reported: Growth retardation[Ref]


Frequency not reported: Rash, maculopapular rash

Betamethasone dipropionate:

-Frequency not reported: Burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hyperpigmentation, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, skin atrophy, striae miliaria, ecchymoses, telangiectasia


-Frequency not reported: Erythema, stinging, blistering, peeling, pruritus, urticaria, general irritation[Ref]


Betamethasone dipropionate:

-Frequency not reported: Sensitization[Ref]


Topical corticosteroids:

-Frequency not reported: Glucosuria[Ref]


Betamethasone dipropionate:

-Frequency not reported: Blurred vision[Ref]


Topical corticosteroids:

-Frequency not reported: Hyperglycemia[Ref]


Frequency not reported: Edema, secondary infection

Betamethasone dipropionate:

-Frequency not reported: Secondary infection


-Frequency not reported: Edema[Ref]

Frequently asked questions


1. "Product Information. Lotrisone (betamethasone-clotrimazole topical)." Apothecon Inc (2022):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.