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Lastacaft Side Effects

Generic name: alcaftadine ophthalmic

Medically reviewed by Last updated on Feb 22, 2021.

Note: This document contains side effect information about alcaftadine ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Lastacaft.

For the Consumer

Applies to alcaftadine ophthalmic: ophthalmic solution

Side effects requiring immediate medical attention

Along with its needed effects, alcaftadine ophthalmic (the active ingredient contained in Lastacaft) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking alcaftadine ophthalmic:

Less common

  • Burning or stinging sensation in the eye
  • itching of the eyes
  • red, sore eyes

Side effects not requiring immediate medical attention

Some side effects of alcaftadine ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • runny nose
  • shivering
  • sore throat
  • stuffy or runny nose
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to alcaftadine ophthalmic: ophthalmic solution


The most commonly reported side effects included eye burning, irritation, and/or stinging following irritation.[Ref]


Frequency not reported: Eye burning/irritation/pruritus/redness/stinging upon instillation

Postmarketing reports: Blurred vision, eye discharge, eye swelling, eyelid edema, eyelid erythema, increased lacrimation[Ref]

Nervous system

Frequency not reported: Headache

Postmarketing reports: Somnolence[Ref]


Frequency not reported: Nasopharyngitis[Ref]


Postmarketing reports: Allergic dermatitis, face swelling[Ref]


Postmarketing reports: Hypersensitivity reactions[Ref]


1. "Product Information. Lastacaft (alcaftadine ophthalmic)." Vistakon, div of Johnson and Johnson Optical, Jacksonville, FL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.