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Generic name: alcaftadine ophthalmical-KAF-ta-deen-off-THAL-mik ]
Drug class: Ophthalmic antihistamines and decongestants

Medically reviewed by Judith Stewart, BPharm. Last updated on Mar 16, 2022.

What is Lastacaft?

Lastacaft is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms such as itchy or watery eyes.

Lastacaft ophthalmic solution is used for the relief of itching in the eyes caused by allergies to pollen, ragweed, grass, animal hair and dander.

Lastacaft should not be used to treat eye irritation caused by contact lenses.

Lastacaft may also be used for purposes not listed in this medication guide.


To make sure you can safely use Lastacaft, tell your doctor about any medical conditions that affect your eyes.

Lastacaft should not be used to treat eye irritation caused by contact lenses.

Before using Lastacaft

You should not use Lastacaft if you are allergic to alcaftadine.

To make sure you can safely use Lastacaft, tell your doctor about any medical conditions that affect your eyes.

Lastacaft is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether alcaftadine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Lastacaft should not be used in a child younger than 2 years old.

How should I use Lastacaft?

Follow the directions on the product package. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Do not use this medication while wearing contact lenses. Lastacaft may contain a preservative that can discolor soft contact lenses. Wait at least 10 minutes after using Lastacaft before putting your contact lenses in. Wash your hands before using eye medication.

To apply the eye drops:

Do not allow the tip of the dropper to touch any surface, including your eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your doctor for a new prescription.

Store Lastacaft at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

Dosing information

Usual Adult and Pediatric Dose for Allergic Conjunctivitis

- 1 drop instilled into each eye once a day

Use: Temporary relief of itchy eyes due to pollen, ragweed, grass, animal hair and dander.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Do not use other eye medications during treatment with Lastacaft unless your doctor tells you to.

Lastacaft side effects

Get emergency medical help if you have any signs of an allergic reaction to Lastacaft: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Lastacaft and call your doctor at once if you have severe burning, stinging, or other irritation after using the eye drops.

Less serious Lastacaft side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lastacaft?

It is not likely that other drugs you take orally or inject will have an effect on Lastacaft used in the eyes. But many drugs can interact with each other. Tell your doctor about all medicines you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lastacaft only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.