Klayesta Side Effects
Generic name: nystatin topical
Medically reviewed by Drugs.com. Last updated on Jul 5, 2024.
Note: This document provides detailed information about Klayesta Side Effects associated with nystatin topical. Some dosage forms listed on this page may not apply specifically to the brand name Klayesta.
Applies to nystatin topical: topical cream, topical ointment, topical powder.
Serious side effects of Klayesta
Along with its needed effects, nystatin topical (the active ingredient contained in Klayesta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking nystatin topical:
- Skin irritation not present before use of this medicine
For healthcare professionals
Applies to nystatin topical: topical cream, topical kit, topical ointment, topical powder, vaginal tablet.
Dermatologic adverse events
Dermatologic side effects associated with nystatin topical (the active ingredient contained in Klayesta) powder, cream, and ointment have included skin irritation, burning, itching, rash, eczema, and pain on application in less than 0.1% of patients.[Ref]
Genitourinary
Genitourinary side effects associated with nystatin vaginal tablets have included vaginal irritation, burning, and itching. At least one case of severe vulvovaginitis has also been reported.[Ref]
A 64-year-old female experienced severe vulvovaginitis while receiving intravaginal nystatin therapy for Candida glabrata infection. She was administered nystatin vaginal tablets, 100,000 units twice daily for 14 days. She returned immediately after having completed the course complaining of intense skin rash in the vulvar area accompanied by severe irritation, burning, and itching. Therapy with a hydrocortisone cream and intramuscular betamethasone dipropionate was initiated. A week later, she had marked improvement with clearing of the vulvovaginal erythema and edema.[Ref]
Hypersensitivity
Hypersensitivity side effects associated with nystatin topical (the active ingredient contained in Klayesta) powder, cream, and ointment have included allergic reactions and allergic contact dermatitis in less than 0.1% of patients. Stevens-Johnson syndrome has also been reported.
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References
1. Hills RJ, Ive FA (1993) "Contact sensitivity to nystatin in Timodine." Contact Dermatitis, 28, p. 48
2. Garty BZ (1991) "Stevens-Johnson syndrome associated with nystatin treatment." Arch Dermatol, 127, p. 741-2
3. Wasilewski C Jr (1971) "Allergic contact dermatitis from nystatin." Arch Dermatol, 104, p. 437
4. Wasilewski C Jr (1970) "Allergic contact dermatitis from nystatin." Arch Dermatol, 102, p. 216-7
5. Quirce S, Parra F, Lazaro M, Gomez MI, Sanchez Cano M (1991) "Generalized dermatitis due to oral nystatin." Contact Dermatitis, 25, p. 197-8
6. Lang E, Goos M (1985) "Combined allergy to tolnaftate and nystatin." Contact Dermatitis, 12, p. 182
7. de Groot AC, Conemans JM (1990) "Nystatin allergy. Petrolatum is not the optimal vehicle for patch testing." Dermatol Clin, 8, p. 153-5
8. (2001) "Product Information. Mycostatin Pastilles (nystatin)." Ernest Jackson & Co. Ltd
9. (2022) "Product Information. Mycostatin (nystatin)." Apothecon Inc
More about Klayesta (nystatin topical)
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- During pregnancy
- Drug class: topical antifungals
- Breastfeeding
Patient resources
Other brands
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Professional resources
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Further information
Klayesta side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.