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Injectafer Side Effects

Generic Name: ferric carboxymaltose

Note: This document contains side effect information about ferric carboxymaltose. Some of the dosage forms listed on this page may not apply to the brand name Injectafer.

For the Consumer

Applies to ferric carboxymaltose: intravenous solution

Along with its needed effects, ferric carboxymaltose (the active ingredient contained in Injectafer) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ferric carboxymaltose:

Less common
  • Blurred vision
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • feeling of warmth
  • headache
  • nervousness
  • pounding in the ears
  • redness of the face, neck, arms, and occasionally, upper chest
  • slow or fast heartbeat
  • sweating
  • unusual tiredness or weakness
Incidence not known
  • Chest discomfort
  • chills
  • cough
  • difficult or labored breathing
  • difficulty swallowing
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • hives
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash
  • tightness in the chest

Some side effects of ferric carboxymaltose may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Less common
  • Change in taste
  • discoloration at the injection site
  • loss of taste
  • vomiting
  • Abdominal or stomach pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • diarrhea
  • difficulty having a bowel movement (stool)
  • pain or irritation at the injection site
  • sneezing
Incidence not known
  • Back pain
  • difficulty with moving
  • hives or welts
  • muscle pain or stiffness
  • pain in the joints
  • redness of the skin

For Healthcare Professionals

Applies to ferric carboxymaltose: intravenous solution


Common (1% to 10%): Flushing/hot flush, hypertension, hypotension
Uncommon (0.1% to 1%): Chest pain, peripheral edema, tachycardia
Rare (less than 0.1%): Phlebitis
Postmarketing reports: Chest discomfort, pallor[Ref]


Uncommon (0.1% to 1%): Erythema, rash, pruritus, urticaria
Postmarketing reports: Angioedema, dermatitis[Ref]


Common (1% to 10%): Nausea, vomiting
Uncommon (0.1% to 1%): Abdominal pain, constipation, diarrhea, dyspepsia
Rare (less than 0.1%): Flatulence[Ref]


Common (1% to 10%): Alanine aminotransferase increase
Uncommon (0.1% to 1%): Aspartate aminotransferase increase, gamma glutamyl transferase increase[Ref]


Common (1% to 10%): Pruritus, rash, urticaria, wheezing, and hypertension associated with hypersensitivity reactions
Rare (less than 0.1%): Serious anaphylactic/anaphylactoid reactions[Ref]


Common (1% to 10%): Injection site reactions[Ref]

Injection site reactions include infusion site burning, -pain, -bruising, -discoloration, -extravasation, -irritation, and -paresthesia.[Ref]


Common (1% to 10%): Blood phosphorus decrease, hypophosphatemia
Uncommon (0.1% to 1%): Blood alkaline phosphatase increase, blood lactate dehydrogenase increase[Ref]


Postmarketing reports: Arthralgia, back pain, hypophosphatemic osteomalacia, muscle spasms, myalgia[Ref]

Nervous system

Common (1% to 10%): Dizziness, dysgeusia, headache
Uncommon (0.1% to 1%): Paraesthesia
Rare (less than 0.1%): Syncope, presyncope
Postmarketing reports: Loss of consciousness[Ref]


Uncommon (0.1% to 1%): Chills, fatigue, pain, pyrexia
Rare (less than 0.1%): Malaise, rigors
Frequency not reported: Overestimate of serum iron and transferrin bound iron laboratory assays
Postmarketing reports: Face edema, vertigo[Ref]


Uncommon (0.1% to 1%): Sneezing
Rare (less than 0.1%): Bronchospasm
Postmarketing reports: Dyspnea[Ref]


Rare (less than 0.1%): Anxiety[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Injectafer (ferric carboxymaltose)." American Regent Laboratories Inc, Shirley, NY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.