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Hyaluronidase / immune globulin Side Effects

In Summary

More frequently reported side effects include: fever, nausea, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to hyaluronidase / immune globulin: subcutaneous solution

Along with its needed effects, hyaluronidase/immune globulin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hyaluronidase / immune globulin:

More Common

  • Fever

Some side effects of hyaluronidase / immune globulin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Headache
  • nausea
  • red streaks on the skin
  • swelling, tenderness, or pain at the injection site
  • unusual tiredness or weakness
  • vomiting

Less Common

  • Itching, redness, swelling, discomfort, or pain at the infusion site

For Healthcare Professionals

Applies to hyaluronidase / immune globulin: subcutaneous solution

General

The most common adverse events were local reactions, headache, antibody formation against recombinant human hyaluronidase (rHuPH20), fatigue, nausea, pyrexia, and vomiting.[Ref]

Local

Very common (10% or more): Local reaction (51.9%)

Frequency not reported: Local pain and swelling, discomfort/pain, erythema, pruritus[Ref]

Nervous system

Very common (10% or more): Headache (21%), fatigue (11.1%)

Postmarketing reports: Transient ischemic attack, tremor, burning sensation, cerebrovascular accident, coma, seizures, loss of consciousness[Ref]

Immunologic

Very common (10% or more): Antibodies to recombinant human hyaluronidase (18%)[Ref]

Other

Very common (10% or more): Systemic adverse reaction (67.9%)

Common (1% to 10%): Pyrexia

Frequency not reported: Fever, back injury, transient swelling from abdominal infusion site to genitalia

Postmarketing reports: Edema, rigors[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting

Postmarketing reports: Abdominal pain[Ref]

Hematologic

Frequency not reported: Acute intravascular hemolysis

Postmarketing reports: Leukopenia, pancytopenia[Ref]

Renal

Frequency not reported: Acute renal dysfunction/failure[Ref]

Cardiovascular

Postmarketing reports: Hypotension, hypertension, myocardial infarction, chest pain, cardiac arrest, vascular collapse[Ref]

Respiratory

Postmarketing reports: Pulmonary edema, dyspnea, oxygen saturation decreased, cyanosis, hypoxemia, bronchospasm, apnea, acute respiratory distress syndrome (ARDS)[Ref]

Dermatologic

Postmarketing reports: Hyperhidrosis, allergic dermatitis, bullous dermatitis, epidermolysis, erythema multiforme, Stevens-Johnson Syndrome[Ref]

Hepatic

Postmarketing reports: Hepatic dysfunction[Ref]

Psychiatric

Postmarketing reports: Anxiety, insomnia[Ref]

Musculoskeletal

Postmarketing reports: Back pain[Ref]

References

1. "Product Information. Hyqvia (hyaluronidase-immune globulin)." Baxter Healthcare Corporation, Deerfield, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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