Hyaluronidase / immune globulin Side Effects
Medically reviewed by Drugs.com. Last updated on May 30, 2022.
More frequently reported side effects include: fever, nausea, and vomiting. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to hyaluronidase/immune globulin: subcutaneous solution
Subcutaneous route (Kit)
Thrombosis may occur with immune globulin/recombinant human hyaluronidase in patients with or without known risk factors. Risk factors may include advanced age, prolonged immobilization, hypercoagulable conditions, history of venous or arterial thrombosis, use of estrogens, indwelling central vascular catheters, hyperviscosity, and cardiovascular risk factors. Adequate hydration prior to administration is recommended. Administer at the minimum dose and infusion rate practicable in patients at risk of thrombosis. Monitor for signs and symptoms of thrombosis and assess blood viscosity in patients at risk of hyperviscosity.
Side effects requiring immediate medical attention
Along with its needed effects, hyaluronidase / immune globulin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking hyaluronidase / immune globulin:
Side effects not requiring immediate medical attention
Some side effects of hyaluronidase / immune globulin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- red streaks on the skin
- swelling, tenderness, or pain at the injection site
- unusual tiredness or weakness
- Itching, redness, swelling, discomfort, or pain at the infusion site
For Healthcare Professionals
Applies to hyaluronidase / immune globulin: subcutaneous solution
The most common adverse events were local reactions, headache, antibody formation against recombinant human hyaluronidase (rHuPH20), fatigue, nausea, pyrexia, and vomiting.[Ref]
Very common (10% or more): Local reaction (51.9%)
Very common (10% or more): Headache (21%), fatigue (11.1%)
Very common (10% or more): Antibodies to recombinant human hyaluronidase (18%)[Ref]
Very common (10% or more): Systemic adverse reaction (67.9%)
Common (1% to 10%): Pyrexia
Frequency not reported: Fever, back injury, transient swelling from abdominal infusion site to genitalia
Common (1% to 10%): Nausea, vomiting
Frequency not reported: Acute intravascular hemolysis
Frequency not reported: Acute renal dysfunction/failure[Ref]
Postmarketing reports: Hepatic dysfunction[Ref]
More about hyaluronidase / immune globulin
- Drug interactions
- Dosage information
- During pregnancy
- Reviews (1)
- En español
- Drug class: immune globulins
Related treatment guides
1. "Product Information. Hyqvia (hyaluronidase-immune globulin)." Baxter Healthcare Corporation (2014):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.