Humatin Side Effects
Generic name: paromomycin
Medically reviewed by Drugs.com. Last updated on Nov 20, 2024.
Note: This document provides detailed information about Humatin Side Effects associated with paromomycin. Some dosage forms listed on this page may not apply specifically to the brand name Humatin.
Applies to paromomycin: oral capsule.
Precautions
It is very important that your doctor check the progress of you or your child at regular visits to make sure that this medicine is working properly.
If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.
Common side effects of Humatin
Some side effects of paromomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Serious side effects of Humatin
Along with its needed effects, paromomycin (the active ingredient contained in Humatin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
For healthcare professionals
Applies to paromomycin: oral capsule.
Gastrointestinal adverse events
- Frequency not reported: Nausea, abdominal cramps, diarrhea, gastrointestinal intolerance, vomiting, abdominal discomfort, pancreatitis, elevated serum amylase[Ref]
Nausea, abdominal cramps, and diarrhea have been reported with doses greater than 3 g/day.
A patient with AIDS developed pancreatitis after 5 days of therapy with this drug for cryptosporidiosis. Serum amylase declined progressively after this drug was discontinued but became elevated after reinstitution of therapy.[Ref]
Nervous system
Ototoxicity and sensorineural damage have been reported, usually in patients who also had hepatic disease.[Ref]
Hepatic
- Frequency not reported: Elevated AST, elevated ALT[Ref]
Transient elevated AST (greater than 3 times the upper limit of normal [3 x ULN]) and ALT (greater than 3 x ULN) were reported in patients receiving an IM formulation during a clinical study.[Ref]
Other
- Frequency not reported: Pyrexia[Ref]
Pyrexia was reported in patients receiving an IM formulation during a clinical study.[Ref]
Local
- Frequency not reported: Injection site pain, injection site swelling[Ref]
Injection site pain and swelling were reported in patients receiving an IM formulation during a clinical study.[Ref]
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References
1. Sullam PM, Slutkin G, Gottlieb AB, Mills J (1986) "Paromomycin therapy of endemic amebiasis in homosexual men." Sex Transm Dis, 13, p. 151-5
2. (2001) "Product Information. Humatin (paromomycin)." Parke-Davis
3. Tan WW, Chapnick EK, Abter EIM, Haddad S, Zimbalist EH, Lutwick LI (1995) "Paromomycin-associated pancreatitis HIV-related cryptosporidiosis." Ann Pharmacother, 29, p. 22-4
4. Sundar S, Jha TK, Thakur CP, Sinha PK, Bhattacharya SK (2007) "Injectable paromomycin for Visceral leishmaniasis in India." N Engl J Med, 356, p. 2571-81
5. Melbourne: Therapeutic Guidelines Limited (2015) eTG complete [Online] http://online.tg.org.au/complete/desktop/tgc.htm
More about Humatin (paromomycin)
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- Drug class: amebicides
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Further information
Humatin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.