Skip to main content

Hemin Side Effects

Medically reviewed by Last updated on Sep 30, 2022.

Applies to hemin: intravenous powder for solution.

Serious side effects of Hemin

Along with its needed effects, hemin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hemin:

Less common

  • Bluish color
  • changes in skin color
  • fever
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • redness or pain at the catheter site
  • swelling of the foot or leg tenderness

Incidence not known

  • Back pain
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • dark urine
  • decreased urination
  • dizziness
  • fainting
  • fever
  • irregular heartbeat
  • lightheadedness
  • pinpoint red spots on the skin
  • stomach pain
  • tiredness
  • unusual bleeding or bruising
  • yellow eyes or skin

Other side effects of Hemin

Some side effects of hemin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Incidence not known

  • Dry, red, hot, or irritated skin

For Healthcare Professionals

Applies to hemin: intravenous powder for injection.


Very common (10% or more): Poor venous access

Postmarketing reports: Thrombocytopenia, coagulopathy (including prolonged prothrombin time and prolonged partial thromboplastin time), hemolysis[Ref]


Rare (0.01% to 0.1%): Anaphylactoid reaction, hypersensitivity (e.g., dermatitis medicamentosa, tongue edema)[Ref]


Common (1% to 10%): Cellulitis[Ref]


Common (1% to 10%): Phlebitis/injection site phlebitis, catheter-related complication (e.g., erythema, pain, bleeding, extravasation, infusion site swelling)[Ref]


Uncommon (0.1% to 1%): Increased serum ferritin

Frequency not reported: Blood creatinine increased

Postmarketing reports: Iron overload[Ref]


Postmarketing reports: Reversible renal shutdown (after administration of excessive doses)[Ref]


Frequency not reported: Phlebitis (with or without leukocytosis and with or without mild pyrexia has occurred after administration of this drug through small arm veins)[Ref]


Frequency not reported: Skin discoloration[Ref]


1. Product Information. Panhematin (hemin). Recordati Rare Diseases Inc. 2001.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.