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Hemin Dosage

Medically reviewed by Drugs.com. Last updated on Aug 23, 2017.

Applies to the following strengths: 313 mg; 350 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Porphyria

1 to 4 mg/kg/day IV for 3 to 14 days based on clinical signs; in more severe cases, this dose may be repeated no earlier than every 12 hours.

Maximum dose: 6 mg/kg per 24 hours

Comments: For moderate to severe attacks, immediate treatment with this drug is recommended. Symptoms of severe attacks are severe or prolonged pain, persistent vomiting, hyponatremia, convulsion, psychosis, and neuropathy.

Use: Amelioration of recurrent attacks of acute intermittent porphyria temporally related to the menstrual cycle in susceptible women, after initial carbohydrate therapy is known or suspected to be inadequate.

Usual Pediatric Dose for Porphyria

16 Years or Older:
1 to 4 mg/kg/day IV for 3 to 14 days based on clinical signs; in more severe cases, this dose may be repeated no earlier than every 12 hours.

Maximum dose: 6 mg/kg per 24 hours

Comments: For moderate to severe attacks, immediate treatment with this drug is recommended. Symptoms of severe attacks are severe or prolonged pain, persistent vomiting, hyponatremia, convulsion, psychosis, and neuropathy.

Use: Amelioration of recurrent attacks of acute intermittent porphyria temporally related to the menstrual cycle in susceptible women, after initial carbohydrate therapy is known or suspected to be inadequate.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

US BOXED WARNINGS:
-ALTERNATE THERAPY: An appropriate period of alternate therapy (i.e., 400 g of glucose per day for 1 to 2 days) must be considered before administering this drug.
-ADMINISTRATION: This drug should only be used by physicians experienced in the management of porphyrias in hospitals where the recommended clinical and laboratory diagnostic and monitoring techniques are available.

Safety and efficacy have not been established in patients younger than 16 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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