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Glyset Side Effects

Generic name: miglitol

Medically reviewed by Last updated on Feb 14, 2023.

Note: This document contains side effect information about miglitol. Some dosage forms listed on this page may not apply to the brand name Glyset.

Applies to miglitol: oral tablet.

Other side effects of Glyset

Some side effects of miglitol (the active ingredient contained in Glyset) may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to miglitol: oral tablet.


The most commonly reported adverse reactions include gastrointestinal symptoms; they tend to diminish in frequency and intensity with time.


Very common (10% or more): Flatulence (41.5%), diarrhea (28.7%), abdominal pain (11.7%)

Postmarketing reports: Pneumatosis cystoides intestinalis (may present with symptoms of diarrhea, mucus discharge, rectal bleeding, and constipation), ileus (including paralytic ileus), subileus, gastrointestinal pain, nausea, abdominal distention.[Ref]

The severity of gastrointestinal symptoms may be decreased by dosage reduction and avoiding high gas-producing foods and sucrose. Some studies have demonstrated a decrease in the severity of gastrointestinal effects over time with continued administration.[Ref]


Common (1% to 10%): Skin rash[Ref]


Common (1% to 10%): Low serum iron[Ref]


1. Product Information. Glyset (miglitol). Bayer. 2001;PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.