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Gadoxetate disodium Side Effects

For the Consumer

Applies to gadoxetate disodium: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by gadoxetate disodium. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking gadoxetate disodium, check with your doctor or nurse immediately:

  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • difficult or labored breathing
  • dizziness
  • fainting
  • fast, slow, or irregular heartbeat
  • feeling hot
  • headache
  • inability to sit still
  • need to keep moving
  • nervousness
  • pounding in the ears
  • restlessness
  • shakiness in the legs, arms, hands, or feet
  • tightness in the chest
  • trembling or shaking of the hands or feet
  • troubled breathing
Incidence not known:
  • Cold, clammy skin
  • confusion
  • fast, weak pulse
  • lightheadedness
  • restlessness
  • sweating

Minor Side Effects

Some of the side effects that can occur with gadoxetate disodium may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

  • Back pain
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • change in sense of smell
  • change in taste
  • dry mouth
  • feeling of constant movement of self or surroundings
  • feeling of warmth
  • general feeling of discomfort or illness
  • increased sweating
  • increased watering of the mouth
  • itching
  • loss of taste
  • nausea
  • rash with flat lesions or small raised lesions on the skin
  • redness of the face, neck, arms, and occasionally, upper chest
  • sensation of spinning
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to gadoxetate disodium: intravenous solution


Cardiovascular side effects have included chest pain, bundle branch block, increased blood pressure, and flushing.[Ref]

Nervous system

Nervous system side effects have included headache, akathisia, dizziness, parosmia, vertigo, tremor, akathisia, and dysgeusia.[Ref]


Respiratory side effects have included dyspnea and respiratory distress.[Ref]


Gastrointestinal side effects have included dry mouth, oral discomfort, salivary hypersecretion, nausea, and vomiting.[Ref]


General side effects have included feeling hot, chills, discomfort, fatigue and malaise.[Ref]


Dermatologic side effects have included maculopapular rash, hyperhidrosis, rash, and pruritus.[Ref]


Local side effects have included injection site reactions (pain, burning, coldness, extravasation).[Ref]


1. "Product Information. Eovist (gadoxetate)." Bayer Pharmaceutical Inc, West Haven, CT.

Not all side effects for gadoxetate disodium may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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