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Generic name: gadoteridolGAD-oh-TER-i-dol ]
Drug class: Magnetic resonance imaging contrast media

Medically reviewed by on Apr 12, 2021. Written by Cerner Multum.

What is Prohance?

Prohance is a contrast agent that has magnetic properties. It is used in combination with magnetic resonance imaging (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI.

Prohance is used to help diagnose certain disorders of the head and neck, or brain and spine (central nervous system).

Prohance may also be used for purposes not listed in this medication guide.


Prohance can cause a life-threatening condition in people with advanced kidney disease. Before receiving Prohance, tell your doctor if you have kidney disease or if you are on dialysis. You may not be able to receive this medicine. Also tell your doctor if you have recently received any contrast agents similar to this medicine.

Before taking this medicine

Prohance can cause a life-threatening condition in people with advanced kidney disease. You should not receive this medication if you have kidney disease or if you are on dialysis.

Prohance can stay in your body for months or years after you receive this medicine. It is not known whether this could cause any health problems in people whose kidneys work properly. Tell your doctor if you have had repeated scans with a contrast agent, and provide the date of your last scan.

You should not receive Prohance if you are allergic to it.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

How is Prohance given?

Prohance is given as an infusion into a vein. A healthcare provider will give you this injection.

Your doctor or other healthcare provider may want to watch you for a short time after your test is over. This is to make sure you do not have any unwanted side effects or delayed reactions.

What happens if I miss a dose?

Since Prohance is used only during your MRI, you will not be on a dosing schedule.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving Prohance?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Prohance side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects of gadoteridol may occur up to several days after injection.

Prohance can cause a life-threatening condition in people with advanced kidney disease. Call your doctor right away if you have any symptoms of this condition, such as:

  • burning, itching, swelling, scaling, and tightening or hardening of your skin;

  • muscle weakness;

  • joint stiffness in your arms, hands, legs, or feet;

  • deep bone pain in your ribs or your hips;

  • trouble moving; or

  • skin redness or discoloration.

Also call your doctor at once if you have:

  • kidney problems--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;

  • a seizure (convulsions); or

  • a light-headed feeling, like you might pass out.

Common side effects of Prohance may include:

  • nausea; or

  • unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Prohance?

Other drugs may affect Prohance, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.