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Gadoteridol

Generic Name: gadoteridol (GAD oh TER i dol)
Brand Name: Prohance

Medically reviewed on January 2, 2018

What is gadoteridol?

Gadoteridol is a contrast agent that produces magnetic effects. It is used in combination with magnetic resonance angiography (MRA) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRA.

Gadoteridol is used to help diagnose certain disorders of the head and neck, or brain and spine (central nervous system).

Gadoteridol may also be used for purposes not listed in this medication guide.

Important Information

Gadoteridol can cause a life-threatening condition in people with advanced kidney disease. Before receiving gadoteridol, tell your doctor if you have kidney disease or if you are on dialysis. You may not be able to receive gadoteridol. Also tell your doctor if you have recently received any contrast agents similar to gadoteridol.

Before taking this medicine

Gadoteridol can cause a life-threatening condition in people with advanced kidney disease. You should not receive this medication if you have kidney disease or if you are on dialysis.

Gadoteridol can stay in your body for months or years after you receive this medicine. It is not known whether this could cause any health problems in people whose kidneys work properly. Tell your doctor if you have had repeated scans with a contrast agent, and provide the date of your last scan.

You should not receive gadoteridol if you are allergic to it.

To make sure gadoteridol is safe for you, tell your doctor if you have ever had:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether gadoteridol passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

How is gadoteridol given?

Gadoteridol is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting during your MRA.

Your doctor or other healthcare provider may want to watch you for a short time after your test is over. This is to make sure you do not have any unwanted side effects or delayed reactions.

What happens if I miss a dose?

Since gadoteridol is used only during your MRA, you will not be on a dosing schedule.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving gadoteridol?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Gadoteridol side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects of gadoteridol may occur up to several days after injection.

Gadoteridol can cause a life-threatening condition in people with advanced kidney disease. Call your doctor right away if you have any symptoms of this condition, such as:

  • burning, itching, swelling, scaling, and tightening or hardening of your skin;

  • muscle weakness;

  • joint stiffness in your arms, hands, legs, or feet;

  • deep bone pain in your ribs or your hips;

  • trouble moving; or

  • skin redness or discoloration.

Also call your doctor at once if you have:

  • kidney problems--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;

  • a seizure (convulsions); or

  • a light-headed feeling, like you might pass out.

Common side effects may include:

  • nausea; or

  • unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Gadoteridol dosing information

Usual Adult Dose for CNS Magnetic Resonance Imaging:

Central Nervous System:
0.1 mmol/kg (0.2 mL/kg) administered as a rapid intravenous infusion (10 mL/min to 60 mL/min) or bolus (greater than 60 mL/min). In patients suspected of having poorly enhancing lesions, in the presence of negative or equivocal scans, a second dose of 0.2 mmol/kg (0.4 mL/kg) may be given up to 30 minutes after the first dose.

Extracranial and Extraspinal Tissues:
0.1 mmol/kg (0.2 mL/kg) administered as a rapid intravenous infusion (10 mL/min to 60 mL/min) or bolus (greater than 60 mL/min).

Usual Pediatric Dose for CNS Magnetic Resonance Imaging:

Central Nervous System - to visualize lesions with abnormal vascularity in the brain (intracranial lesions), spine and associated tissues:
over 2 years of age:
0.1 mmol/kg (0.2 mL/kg) administered as a rapid intravenous infusion (10 mL/min to 60 mL/min) or bolus (greater than 60 mL/min).

What other drugs will affect gadoteridol?

Other drugs may interact with gadoteridol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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