Ethinyl Estradiol Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 17, 2024.

Applies to ethinyl estradiol: compounding powder, oral tablet.

Cardiovascular

• Frequency not reported: Hypertension, thrombosis, thrombophlebitis, thromboembolism, myocardial infarction, stroke^[Ref]

Dermatologic

• Frequency not reported: Erythema nodosum, erythema multiforme, vascular purpura, rash, chloasma^[Ref]

Gastrointestinal

• Frequency not reported: Nausea, vomiting^[Ref]

Genitourinary

• Frequency not reported: Intermenstrual bleeding, increase in the size of uterine fibromyomata, endometrial proliferation or aggravation of endometriosis, excessive production of cervical mucus, breast tenderness, breast pain, breast enlargement, breast secretion^[Ref]

Hematologic

• Frequency not reported: Venous thromboembolism (e.g., deep leg or pelvic venous thrombosis)^[Ref]

Hepatic

• Frequency not reported: Cholelithiasis, cholestatic jaundice^[Ref]

Metabolic

• Frequency not reported: Sodium and water retention, reduced glucose tolerance, change in body weight, hypercalcemia, feminization in males, gynecomastia, testicular atrophy, male impotence^[Ref]

Nervous system

• Frequency not reported: Headache, migraine, dizziness^[Ref]

Ocular

• Frequency not reported: Corneal discomfort (if contact lenses are used)^[Ref]

Oncologic

• Frequency not reported: Endometrial neoplasia, endometrial cancer, breast cancer^[Ref]

Psychiatric

• Frequency not reported: Mood changes (e.g., elation, depression), probable dementia^[Ref]

Frequently asked questions

• When do I start taking Diane pills for birth control?

Further information

Ethinyl estradiol side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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