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Epiduo Forte Side Effects

Generic Name: adapalene / benzoyl peroxide topical

Note: This document contains side effect information about adapalene / benzoyl peroxide topical. Some of the dosage forms listed on this page may not apply to the brand name Epiduo Forte.

In Summary

Common side effects of Epiduo Forte include: burning sensation of skin, desquamation, stinging of the skin, erythema, and xeroderma. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to adapalene/benzoyl peroxide topical: topical application gel/jelly

Along with its needed effects, adapalene/benzoyl peroxide topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking adapalene / benzoyl peroxide topical:

More common
  • Dryness and peeling of the skin
  • flushing or redness of the skin
  • unusually warm skin
Less common
  • Blistering, burning, crusting, or flaking of the skin
  • burning, itching, redness, skin rash, swelling, or soreness at the application site
  • scaling, severe redness, or swelling of the skin
Incidence not known

Some side effects of adapalene / benzoyl peroxide topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Burning, dry, or itching eyes
  • change in the color of the treated skin
  • discharge or excessive tearing
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • skin rash, encrusted, scaly, and oozing
  • swelling of the face

For Healthcare Professionals

Applies to adapalene / benzoyl peroxide topical: topical gel


The most commonly reported side effects include irritative contact dermatitis, burning sensation, and dry skin.[Ref]


Common (1% to 10%): Irritative contact dermatitis, dry skin/dryness, skin irritation, erythema, skin exfoliation/scaling
Uncommon (0.1% to 1%): Sunburn, pruritus, atopic dermatitis, eczema
Frequency not reported: Skin pain/stinging pain
Postmarketing reports: Allergic contract dermatitis, blisters/vesicles, skin discoloration, rash[Ref]


Common (1% to 10%): Application site burning, application site irritation[Ref]

Nervous system

Common (1% to 10%): Burning sensation/skin burning sensation[Ref]


Postmarketing reports: Eyelid edema, conjunctivitis[Ref]


Postmarketing reports: Throat tightness[Ref]


Postmarketing reports: Swelling face[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Epiduo (adapalene-benzoyl peroxide topical)." Galderma Laboratories Inc, Cranbury, NJ.

Some side effects of Epiduo Forte may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.