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Eloxatin Side Effects

Generic name: oxaliplatin

Medically reviewed by Philip Thornton, DipPharm. Last updated on Mar 14, 2022.

Note: This document contains side effect information about oxaliplatin. Some of the dosage forms listed on this page may not apply to the brand name Eloxatin.

For the Consumer

Applies to oxaliplatin: intravenous powder for solution, intravenous solution


Intravenous route (Solution; Powder for Solution)

Hypersensitivity Reactions, including AnaphylaxisSerious and fatal hypersensitivity adverse reactions, including anaphylaxis, can occur with oxaliplatin within minutes of administration and during any cycle. Oxaliplatin is contraindicated in patients with hypersensitivity reactions to oxaliplatin and other platinum-based drugs. Immediately and permanently discontinue oxaliplatin for hypersensitivity reactions and administer appropriate treatment.

Side effects requiring immediate medical attention

Along with its needed effects, oxaliplatin (the active ingredient contained in Eloxatin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking oxaliplatin:

More common

  • Abnormal tongue sensation
  • black, tarry stools
  • bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • bleeding gums
  • blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet
  • blood in the urine or stools
  • burning, prickling, itching, or tingling of the skin
  • chest pain
  • chills
  • cough
  • decreased urination
  • difficulty performing daily activities such as writing, buttoning, swallowing, or walking
  • difficulty with articulating words
  • difficulty with breathing
  • difficulty with moving
  • difficulty with swallowing
  • dizziness
  • dry mouth
  • eye pain
  • fainting
  • fever
  • increase in heart rate
  • jaw spasm
  • lightheadedness
  • lower back or side pain
  • muscle pain or stiffness
  • numbness or painful sensations
  • pain in the chest, groin, or legs, especially the calves
  • pain in the joints
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • rapid breathing
  • sensation of pins and needles
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stabbing pain
  • sunken eyes
  • swelling
  • swelling or inflammation of the mouth
  • swollen glands
  • thirst
  • troubled breathing with exertion
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vision changes
  • wrinkled skin

Less common

Incidence not known

  • Back, leg, or stomach pains
  • blindness
  • bloated stomach
  • blue-yellow color blindness
  • blurred vision
  • changes in patterns and rhythms of speech
  • dark urine
  • deafness
  • decreased vision
  • deep breathing
  • drowsiness
  • electric shock-like sensation that moves down the back and into the legs following a bending movement of the neck
  • general body swelling
  • increased urination
  • irregular heartbeat, recurrent
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of deep tendon reflexes
  • muscle cramps or spasms
  • muscle tremors
  • pain and fullness in the right upper abdomen or stomach
  • restlessness
  • severe constipation
  • severe diarrhea
  • severe nosebleeds
  • severe stomach cramps or tenderness
  • severe vomiting
  • trouble with speaking
  • twitches of the muscle visible under the skin
  • weakness of the muscles in your face
  • weight gain
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking oxaliplatin:

Symptoms of overdose

  • Agitation
  • coma
  • cough or hoarseness
  • diarrhea
  • disorientation
  • involuntary, rapid, or rhythmic movement of the eyes
  • lack of coordination
  • lack of sensation
  • lethargy
  • paralysis
  • respiratory failure
  • seizures
  • slow or irregular heartbeat
  • tremors
  • vomiting, profuse

Side effects not requiring immediate medical attention

Some side effects of oxaliplatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Bad, unusual, or unpleasant (after) taste
  • bloated or full feeling
  • bloody nose
  • burning while urinating
  • change in taste
  • congestion
  • cracked lips
  • dryness or soreness of the throat
  • excess air or gas in stomach or intestines
  • feeling of warmth
  • hair loss
  • passing gas
  • rapid weight gain
  • redness of the face, neck, arms, and occasionally upper chest
  • tender, swollen glands in the neck
  • thinning of the hair
  • unusual tearing of the eyes
  • voice changes

For Healthcare Professionals

Applies to oxaliplatin: intravenous powder for injection, intravenous solution

Nervous system

Very common (10% or more): Peripheral sensory neuropathy/paresthesia (92%), pharyngo-laryngeal dysesthesia (38.2%), headache (17%), taste perversion (14%), dizziness (13%), neurosensory reactions (12%), dysgeusia, rigors/tremors

Common (1% to 10%): Sensory disturbance, neuralgia, neuro NOS (not otherwise specified), vertigo, syncope, ataxia, somnolence, intracerebral bleeding, abnormal tongue sensation

Rare (less than 0.1%): Dysarthria/aphasia, RPLS/PRES

Frequency not reported: Vocal cord paralysis, aphonia/dysphonia/hoarseness, trigeminal neuralgia/facial pain, myoclonus, abnormal coordination/abnormal gait, ataxia/balance disorders

Postmarketing reports: Loss of deep tendon reflexes, Lhermitte's sign, cranial nerve palsies, fasciculations, convulsion[Ref]


Very common (10% or more): Anemia (85.2%), leukopenia (85%), neutropenia (82.2%), granulocytopenia (78.9%), thrombocytopenia (77.4%), fever without neutropenia (33%), infection - normal ANC (10%)

Common (1% to 10%): Leukopenia, infection - low ANC, lymphopenia, febrile neutropenia, immune-allergic thrombocytopenia prolongation of prothrombin time and INR, neutropenic sepsis

Rare (less than 0.1%): Autoimmune hemolytic anemia

Postmarketing reports: Hemolytic uremic syndrome[Ref]


Very common (10% or more): Nausea (74%), diarrhea (67%), vomiting (54.1%), stomatitis/mucositis (44%), abdominal pain (33%), constipation (32%), anorexia (29%), dyspepsia (14%), diarrhea - colostomy (13%)

Common (1% to 10%): Gastrointestinal NOS (not otherwise specified), flatulence, dry mouth, rectal bleeding, rectal pain, rectal hemorrhage, gastrointestinal reflux, ascites, hemorrhoids, melena, proctitis, intestinal obstruction, gingivitis, tenesmus, enlarged abdomen, vaginal hemorrhage

Frequency not reported: Gastrointestinal bleeding

Postmarketing reports: Colitis, Clostridium difficile diarrhea, ileus, pancreatitis[Ref]


Very common (10% or more): Fatigue (70.3%), infection (31.6%), fever (29%), asthenia (23.4%), edema (15%), pain (15%), peripheral edema (10%)

Common (1% to 10%): Death, catheter infection, chest pain, unknown infection, feeling of chest pressure

Uncommon (0.1% to 1%): Ototoxicity

Postmarketing reports: Deafness, septic shock[Ref]


Very common (10% or more): Alopecia (67%), skin disorder (35.5%), sweating (12%), hand-foot syndrome (11%), rash (11%)

Common (1% to 10%): Pruritus, dry skin, nail changes, pigmentation changes, urticaria, erythematous rash, purpura[Ref]


Very common (10% or more): Increased transaminases (57%), abnormal alkaline phosphatase (56.5%), abnormal AST (54%), abnormal ALT (36%), bilirubinemia (20%)

Postmarketing reports: Liver veno-occlusive disease/sinusoidal obstruction syndrome, perisinusoidal fibrosis[Ref]


Very common (10% or more): Cough (35%), dyspnea (20%), epistaxis (16%), rhinitis (15%), allergic rhinitis (10%), upper respiratory tract infection (10%)

Common (1% to 10%): Hiccups, pneumonitis, other pulmonary reaction, hypoxia, pharyngitis, hemoptysis, pneumonia, bronchospasm

Rare (less than 0.1%): Acute interstitial lung disease, pulmonary fibrosis

Frequency not reported: Throat tightness/pressure/discomfort/pain

Postmarketing reports: Laryngospasm, other interstitial lung diseases[Ref]


Very common (10% or more): Anorexia (35%), hyperglycemia (14%), hypokalemia (11%), decreased weight (11%), increased weight (10%)

Common (1% to 10%): Dehydration, hypoalbuminemia, hyponatremia, hypocalcemia, elevated creatinine, other metabolic reactions

Postmarketing reports: Metabolic acidosis[Ref]


Very common (10% or more): Back pain (19%), myalgia (14%), arthralgia (10%)

Common (1% to 10%): Bone pain, muscle weakness, involuntary muscle contractions, jaw spasm/muscle spasm/muscle contractions

Frequency not reported: Muscle twitching

Postmarketing reports: Rhabdomyolysis[Ref]


Very common (10% or more): Insomnia (13%)

Common (1% to 10%): Depression, anxiety, nervousness[Ref]


Very common (10% or more): Hypersensitivity reaction (12%), allergic reaction (10.3%)

Postmarketing reports: Angioedema, anaphylactic shock[Ref]


Very common (10% or more): Injection site reaction (11.1%)

Frequency not reported: Extravasation[Ref]


Very common (10% or more): Flushing (10%)

Common (1% to 10%): Thrombosis/phlebitis, thromboembolism, hypotension, hypertension, tachycardia, hot flashes

Postmarketing reports: QT prolongation, ventricular arrhythmias, Torsade de Pointes[Ref]


Common (1% to 10%): Abnormal micturition frequency, dysuria, hematuria, urinary incontinence[Ref]


Common (1% to 10%): Conjunctivitis, abnormal lacrimation, abnormal vision, tearing

Rare (less than 0.1%): Optic neuritis

Frequency not reported: Ptosis, diplopia, eye pain

Postmarketing reports: Decreased visual acuity, visual field disturbance/disorders, transient/reversible vision loss[Ref]


Common (1% to 10%): Secondary malignancies[Ref]


Common (1% to 10%): Altered renal function

Very rare (less than 0.01%): Renal tubular necrosis

Postmarketing reports: Acute interstitial nephritis, acute renal failure[Ref]


1. "Product Information. Eloxatin (oxaliplatin)." Sanofi Winthrop Pharmaceuticals (2002):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.