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Elotuzumab Side Effects

In Summary

More frequently reported side effects include: fever. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to elotuzumab: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by elotuzumab. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking elotuzumab, check with your doctor or nurse immediately:

More common:
  • Blurred vision
  • body aches or pain
  • chest pain
  • chills
  • confusion
  • cough or hoarseness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • ear congestion
  • facial swelling
  • fever or chills
  • headache
  • hives, itching, or rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • nausea or vomiting
  • nervousness
  • painful or difficult urination
  • pounding in the ears
  • redness of the skin
  • runny nose
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual tiredness or weakness
Less common:
  • Abdominal pain or tenderness
  • clay-colored stools
  • dark urine
  • loss of appetite
  • persistent sore that does not heal
  • pink skin growth
  • reddish patch or irritated area
  • shiny skin bump
  • swelling of the feet or lower legs
  • white, yellow or waxy scar-like area on the skin
  • yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with elotuzumab may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Blindness
  • burning, numbness, tingling, or painful sensations
  • decreased appetite
  • decreased vision
  • decreased weight
  • diarrhea
  • difficulty having a bowel movement (stool)
  • muscle aches
  • night sweats
  • pain in the arms or legs
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

For Healthcare Professionals

Applies to elotuzumab: intravenous powder for injection


Common (1% to 10%): Night sweats[Ref]


Very common (10% or more): Diarrhea (47%), constipation (36%), vomiting (15%), oropharyngeal pain (10%)[Ref]


Very common (10% or more): Lymphopenia (13%)
Frequency not reported: Leukopenia, thrombocytopenia, deep vein thrombosis[Ref]


Frequency not reported: Hypoalbuminemia, elevated alkaline phosphatase[Ref]


Common (1% to 10%): Hypersensitivity
Uncommon (0.1% to 1%): Anaphylactic reaction[Ref]


Very common (10% or more): Decreased appetite (21%), weight loss (14%)
Frequency not reported: Hyperglycemia, hypocalcemia, low bicarbonate, hyperkalemia[Ref]


Very common (10% or more): Pain in extremities (16%)
Common (1% to 10%): Chest pain[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (27%), headache (15%)
Common (1% to 10%): Hypoesthesia[Ref]


Very common (10% or more): Cataracts (12%)[Ref]


Common (1% to 10%): Invasive second primary malignancies (SPM)[Ref]


Very common (10% or more): Fatigue (62%), pyrexia (37%)[Ref]


Common (1% to 10%): Altered mood[Ref]


Common (1% to 10%): Acute renal failure[Ref]


Very common (10% or more): Cough (34%), nasopharyngitis (25%), upper respiratory tract infection (23%), pneumonia (20%)
Common (1% to 10%): Respiratory tract infection, pulmonary embolism[Ref]


Very common (10% or more): Herpes zoster[Ref]


Common (1% to 10%): Infusion related reaction[Ref]


1. "Product Information. Empliciti (elotuzumab)." Bristol-Myers Squibb, Princeton, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for elotuzumab may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.