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Doxapram Side Effects

For the Consumer

Applies to doxapram: parenteral injection

Side effects include:

Cough, dyspnea, tachypnea, headache, dizziness, apprehension, hypertension, flushing, sweating, nausea, vomiting, diarrhea, urinary retention, muscle spasticity.

For Healthcare Professionals

Applies to doxapram: intravenous solution


-In preterm neonates and infants, this drug has caused significant QT interval prolongation (associated with atrioventricular block in some cases), bloody stools, abdominal distension, necrotizing enterocolitis, multiple gastric perforations/increased gastric residuals, neurodevelopmental delay, vomiting, premature teeth eruption, hypertension, irritability, jitteriness, hyperglycemia, glucosuria, erratic limb movements, excessive crying, and disturbed sleep.
-Seizures have occurred in premature neonates with risk factors such as a previous seizure, perinatal asphyxia, or intracerebral hemorrhage. In many cases, this drug was given following administration of xanthine derivatives (e.g., caffeine, aminophylline, or theophylline).[Ref]


Frequency not reported: Phlebitis, heart rate variations, lowered T-waves, arrhythmia, ventricular tachycardia, sinus tachycardia, ventricular fibrillation, bradycardia, extrasystole, chest pain, chest tightness, increased blood pressure, flushing[Ref]


Frequency not reported: Pruritus, sweating[Ref]


Frequency not reported: Nausea, vomiting, diarrhea, defecation desire, salivation[Ref]


Frequency not reported: Urinary retention, urinary bladder stimulation with spontaneous voiding, elevated BUN, albuminuria[Ref]


Frequency not reported: Hemolysis, decreased hemoglobin, decreased hematocrit, decreased red blood cell count, decreased white blood cell count (in presence of pre-existing leukopenia)[Ref]


Frequency not reported: Muscle spasticity, muscle fasciculation, increased deep tendon reflexes, clonus, bilateral Babinski[Ref]

Nervous system

Frequency not reported: Paresthesia, headache, dizziness, hyperactivity, involuntary movement, convulsion, decreased cerebral blood flow velocity[Ref]


Frequency not reported: Pupillary dilation[Ref]


Frequency not reported: Pyrexia, perineal warmth[Ref]


Frequency not reported: Apprehension, disorientation, hallucination, confusion[Ref]


Frequency not reported: Dyspnea, cough, hyperventilation, tachypnea, laryngospasm, bronchospasm, hiccough, rebound hyperventilation[Ref]


1. "Product Information. Dopram (doxapram)." West-Ward Pharmaceutical Corporation, Eatontown, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of doxapram may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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