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Doripenem Side Effects

Medically reviewed by Last updated on Feb 26, 2024.

Applies to doripenem: intravenous powder for injection.


You should not receive this medicine if you are allergic to doripenem, ertapenem (Invanz), imipenem (Primaxin), or meropenem (Merrem).

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to doripenem: intravenous powder for injection.


In 5 clinical trials, 1338 adult patients received this drug. The most common side effects were anemia, headache, nausea, diarrhea, rash, elevated hepatic enzymes, and phlebitis. During clinical studies, this drug was discontinued due to side effects in 4.1% of patients.[Ref]

Nervous system

Very common (10% or more): Headache (up to 16%)

Frequency not reported: Dizziness

Postmarketing reports: Seizure[Ref]


Very common (10% or more): Nausea (up to 12%), diarrhea (up to 12%)

Common (1% to 10%): Oral candidiasis

Uncommon (0.1% to 1%): Clostridium difficile colitis

Frequency not reported: Constipation, abdominal pain, dyspepsia[Ref]


Frequency not reported: Hypersensitivity reactions

Postmarketing reports: Anaphylaxis[Ref]

Serious and sometimes fatal hypersensitivity (anaphylactic) reactions have been reported with beta-lactams.[Ref]


Common (1% to 10%): Anemia

Postmarketing reports: Neutropenia, leukopenia, thrombocytopenia[Ref]


Common (1% to 10%): Phlebitis

Frequency not reported: Atrial fibrillation, atrial flutter, hypertension, hypotension[Ref]


Elevated hepatic enzymes also included ALT or AST at or below the upper limit of normal (ULN) at baseline increasing to greater than 5 times ULN at end of therapy.[Ref]

Common (1% to 10%): Elevated hepatic enzymes (includes elevated ALT, elevated AST, elevated transaminases)

Frequency not reported: Cholestasis[Ref]


The incidence of rash was higher in patients receiving doses greater than the approved dose compared to those receiving the approved dose. The rash resolved within 10 days after this drug was stopped.

Serious skin reactions have been reported with beta-lactams.[Ref]

Common (1% to 10%): Rash, pruritus

Frequency not reported: Erythema, macular/papular eruptions, bullous dermatitis, urticaria, erythema multiforme, allergic dermatitis, decubitus ulcer

Postmarketing reports: Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref]


Common (1% to 10%): Vulvomycotic infection

Frequency not reported: Urinary tract infection, asymptomatic bacteriuria[Ref]


Frequency not reported: Pneumonitis, pneumonia, pleural effusion, dyspnea

Postmarketing reports: Interstitial pneumonia[Ref]

Pneumonitis has been reported when this drug was administered via inhalation.[Ref]


Postmarketing reports: Renal impairment/renal failure[Ref]


Frequency not reported: Hypokalemia[Ref]


Frequency not reported: Pyrexia, peripheral edema[Ref]


Frequency not reported: Insomnia, anxiety[Ref]


1. EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports.

2. (2007) "Product Information. Doribax (doripenem)." Ortho McNeil Pharmaceutical

3. (2008) "Doripenem (Doribax)--a new parenteral carbapenem." Med Lett Drugs Ther, 50, p. 5-7

4. Cerner Multum, Inc. "Australian Product Information."

5. Chastre J, Wunderink R, Prokocimer P, Lee M, Kaniga K, Friedland I (2008) "Efficacy and safety of intravenous infusion of doripenem versus imipenem in ventilator-associated pneumonia: a multicenter, randomized study." Crit Care Med, 36, p. 1089-96

6. (2008) "Doripenem (doribax)--a new parenteral carbapenem." Obstet Gynecol, 111, p. 1206-7

7. Cerner Multum, Inc (2015) "Malaysia product information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.