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Generic Name: doripenem (dor i PEN em)
Brand Names: Doribax

What is Doribax?

Doribax (doripenem) is an antibiotic that fights bacteria.

Doribax is used to treat severe infections of the stomach, bladder, or kidneys.

Doribax may also be used for purposes not listed in this medication guide.

Important information

You should not receive Doribax if you are allergic to doripenem, ertapenem (Invanz), imipenem (Primaxin), or meropenem (Merrem).

To make sure Doribax is safe for you, tell your doctor if you have kidney disease, seizures, a history of allergy to a penicillin antibiotic.

Tell your doctor if you also use probenecid or valproic acid.

Call your doctor at once if you have a severe skin rash, or diarrhea that is watery or bloody.

Before receiving Doribax

You should not be treated with Doribax if you are allergic to doripenem, ertapenem (Invanz), imipenem (Primaxin), or meropenem (Merrem).

To make sure Doribax is safe for you, tell your doctor if you have:

  • kidney disease;

  • a history of stroke or seizure; or

  • a history of allergy to penicillin antibiotics such as Amoxil, Augmentin, Bactocill, Bicillin L-A, Dycill, Dynapen, Moxatag, Omnipen, Principen, PC Pen VK, Pfizerpen, Ticar, Timentin, Unasyn, and others.

Doribax is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether doripenem passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How is Doribax given?

Use Doribax exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Doribax is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Doribax is usually given for 5 days to 2 weeks, depending on the condition being treated. You may be switched to an oral (pill form) antibiotic after the first few days of receiving doripenem by injection.

Doribax is a powder that must be mixed with a liquid (diluent). You will need to place the doripenem and diluent mixture in an IV bag of infusion solution before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine. Ask your pharmacist if you have questions.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Doribax will not treat a viral infection such as the common cold or flu.

After mixing the doripenem and diluent mixture with an IV infusion solution, you may store it at room temperature or in a refrigerator. Do not freeze.

At room temperature: You may store the mixture for up to 4 hours if your infusion solution is 5% dextrose, or up to 12 hours if your infusion solution is normal saline.

In a refrigerator: You may store the mixture for up to 24 hours if your infusion solution is 5% dextrose, or up to 72 hours if your infusion solution is normal saline.

Doribax does not contain a preservative. Throw away any Doribax mixture not used within the correct number of hours based on your infusion solution and storage method.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of Doribax.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop using Doribax and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Doribax side effects

Get emergency medical help if you have any signs of an allergic reaction to Doribax: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain;

  • diarrhea that is watery or bloody; or

  • severe itching or skin rash.

Common Doribax side effects may include:

  • headache;

  • diarrhea, nausea;

  • vaginal itching or discharge;

  • mild rash; or

  • pain, swelling, or redness where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Doribax?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Doribax, especially:

  • probenecid; or

  • valproic acid.

This list is not complete. Other drugs may interact with Doribax, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about Doribax.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Doribax only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2018 Cerner Multum, Inc. Version: 1.07. Revision Date: 2015-11-16, 11:52:02 AM.